Uberos, JAguilera-Rodríguez, EJerez-Calero, AMolina-Oya, MMolina-Carballo, ANarbona-López, E2023-01-252023-01-252017-04-26http://hdl.handle.net/10668/11132The aim of the study was to determine whether routine probiotic supplementation (RPS) with Lactobacillus rhamnosus GG (LGG) or Lactobacillus acidophilus +Lactobacillus bifidum is associated with reduced risk of necrotising enterocolitis (NEC)≥Stage II in preterm neonates born at ≤32 weeks' gestation. We conducted a retrospective cohort study on the effect of probiotic supplementation in very low birth weight infants in our neonatal unit by comparing two periods: before and after supplementation. The incidence of NEC≥Stage II, late-onset sepsis and all-cause mortality was compared for an equal period 'before' (Period I) and 'after' (Period II) RPS with LGG or L. acidophillus+L. bifidum. Multivariate logistic regression analysis was conducted to adjust for relevant confounders. The study population was composed of 261 neonates (Period I v. II: 134 v. 127) with comparable gestation duration and birth weights. InenLactobacillusLactobacillus acidophillusLactobacillus bifidumrhamnosus GGLGG Lactobacillus rhamnosus GGNEC necrotising enterocolitisVLBW very low birth weightLate-onset sepsisNecrotising enterocolitisProbioticsVery low birth weight infantsCohort StudiesCombined Modality TherapyCross InfectionEnterocolitis, NecrotizingGastrointestinal MicrobiomeHumansIncidenceInfantInfant MortalityInfant Nutritional Physiological PhenomenaInfant, NewbornInfant, Premature, DiseasesInfant, Very Low Birth WeightIntensive Care Units, NeonatalLactobacillus acidophilusLevilactobacillus brevisLacticaseibacillus rhamnosusPractice Guidelines as TopicPremature BirthProbioticsRetrospective StudiesRiskSepsisSpainresearch article28443531open access10.1017/S00071145170007691475-2662https://www.cambridge.org/core/services/aop-cambridge-core/content/view/0E9FC401C3ECD29E49360C287B1306F3/S0007114517000769a.pdf/div-class-title-probiotics-to-prevent-necrotising-enterocolitis-and-nosocomial-infection-in-very-low-birth-weight-preterm-infants-div.pdf