González-Moles, Miguel ÁngelRamos-García, PabloEsteban, Francisco2022-09-292022-09-292021-03-17González-Moles MÁ, Ramos-García P, Esteban F. Significance of the Overexpression of Substance P and Its Receptor NK-1R in Head and Neck Carcinogenesis: A Systematic Review and Meta-Analysis. Cancers. 2021 Mar 17;13(6):1349http://hdl.handle.net/10668/4183The objective of our study has been, through a systematic review and meta-analysis, to increase the scientific evidence on the implications of SP and its receptor NK-1R in head and neck carcinogenesis. We searched studies published before May-2020 without date and publication language restrictions (PubMed, Embase, Web of Science, Scopus). We evaluated the quality of the studies included (QUIPS tool). We performed heterogeneity, sensitivity, small-study effects, and subgroup analyses. A total 16 studies and 1308 cases met inclusion criteria. Qualitative evaluation demonstrated that not all studies were performed with the same scientific rigor, finding the greatest risk of bias in the study confounding and prognostic factors measurement domains. Quantitative evaluation showed a greater SP/NK-1R overexpression in malignant head and neck lesions compared to benign lesions (p = 0.02), and that expression was observed in malignant salivary gland pathology. Likewise, we found a higher overexpression of NK-1R compared to SP (p = 0.02). In conclusion, the results of this systematic review and meta-analysis show evidence that the upregulation of SP and NK-1R are oncogenic events involved in head and neck carcinogenesis, probably acting in the early stages of malignization. In addition, there is evidence of a greater relevance of the upregulation of the NK-1R receptor compared to SP, which highlights the interest in deepening the development of targeted therapies on the receptor. Future studies assessing the relationships between SP/NK-1R among subjects with head and neck tumors could consider the recommendations given in this systematic review and meta-analysis to improve and standardize future research.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Substance PNK-1RNeurokininTachykininHead and neckNeoplasmSquamous cell carcinomaSystematic reviewMeta-analysisReceptores de neuroquinina-1TaquicininasCabezaCuelloNeoplasiasCarcinoma de células escamosasRevisión sistemáticaMetaanálisisNeoplasias de cabeza y cuelloMedical Subject Headings::Information Science::Information Science::Communication::LanguageMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::PrognosisMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Up-RegulationMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck NeoplasmsMedical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract::Mouth::Salivary GlandsMedical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::CarcinogenesisMedical Subject Headings::Information Science::Information Science::Information Storage and Retrieval::Databases as Topic::Databases, Bibliographic::PubMedMedical Subject Headings::Information Science::Information Science::Information Services::Bibliography as Topic::BibliometricsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Neurotransmitter::Receptors, Neuropeptide::Receptors, Tachykinin::Receptors, Neurokinin-1Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasmsreview article33802704open access10.3390/cancers130613492072-6694PMC8002440