Hidalgo-Moyano, CristinaRangel-Zuñiga, Oriol AlbertoGomez-Delgado, FranciscoAlcala-Diaz, Juan FRodriguez-Cantalejo, FernandoYubero-Serrano, Elena MTorres-Peña, Jose DArenas-de Larriva, Antonio PCamargo, AntonioPerez-Martinez, PabloLopez-Miranda, JoseDelgado-Lista, Javier2023-05-032023-05-032022-09-12Hidalgo-Moyano C, Rangel-Zuñiga OA, Gomez-Delgado F, Alcala-Diaz JF, Rodriguez-Cantalejo F, Yubero-Serrano EM, et al. Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study. Nutrients. 2022 Sep 14;14(18):3789http://hdl.handle.net/10668/21503We investigated whether long-term consumption of two healthy diets (low-fat (LF) or Mediterranean (Med)) interacts with SIRT1 genotypes to modulate aging-related processes such as leucocyte telomere length (LTL), oxidative stress (OxS) and inflammation in patients with coronary heart disease (CHD). LTL, inflammation, OxS markers (at baseline and after 4 years of follow-up) and SIRT1-Single Nucleotide Polymorphisms (SNPs) (rs7069102 and rs1885472) were determined in patients from the CORDIOPREV study. We analyzed the genotype-marker interactions and the effect of diet on these interactions. Regardless of the diet, we observed LTL maintenance in GG-carriers for the rs7069102, in contrast to carriers of the minor C allele, where it decreased after follow-up (p = 0.001). The GG-carriers showed an increase in reduced/oxidized glutathione (GSH/GSSG) ratio (p = 0.003), lower lipid peroxidation products (LPO) levels (p< 0.001) and a greater decrease in tumor necrosis factor-alpha (TNF-α) levels (p < 0.001) after follow-up. After the LF diet intervention, the GGcarriers showed stabilization in LTL which was significant compared to the C allele subjects (p = 0.037), although the protective effects found for inflammation and OxS markers remained significant after follow-up with the two diets. Patients who are homozygous for the SIRT1-SNP rs7069102 (the most common genotype) may benefit from healthy diets, as suggested by improvements in OxS and inflammation in patients with CHD, which may indicate the slowing-down of the aging process and its related diseases.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Aging-related processesCoronary heart diseaseGenetic variantsHealthy dietsRole of sirtuinsAgingCoronary DiseaseDiet, MediterraneanGenotypeGlutathione DisulfideHumansInflammationPolymorphism, Single NucleotideSirtuin 1Tumor Necrosis Factor-alpharesearch article36145164open accessDieta mediterráneaDisulfuro de glutatiónEnfermedad coronariaEnvejecimientoFactor de necrosis tumoral alfaGenotipoInflamaciónPolimorfismo de nucleótido simple10.3390/nu141837892072-6643PMC9504765https://www.mdpi.com/2072-6643/14/18/3789/pdf?version=1663151137https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504765/pdf