Martínez, CarmenCarpio, CeciliaHeras, InmaculadaRíos-Herranz, EduardoBuch, JoanGutierrez, AntonioRomero, SamuelZeberio, IzaskunGarcía-García, IreneRodriguez-Izquierdo, AntoniaAlonso, RosalíaBargay, JoanBarrenetxea, CristinaDomingo-Doménech, Evade Haro, Manuel EspesoPalomera, LuisGarcía-Sanz, RamónSpanish Group of Lymphoma and Bone Marrow Transplantation (GELTAMO)2023-02-082023-02-082020-02-14http://hdl.handle.net/10668/15119Clinical trials have shown that nivolumab has remarkable activity against relapsed/refractory classical Hodgkin lymphoma (cHL). However, the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) as consolidation therapy in these patients remains controversial. We performed a retrospective analysis of data from 74 patients treated with nivolumab. The overall response rate was 58% (including 30.6% with complete responses). Treatment-related adverse events were reported in 56.8% of patients (grade ≥3 in 9.4%). The main reasons for nivolumab discontinuation were referral for transplantation (41.7% patients) and disease progression (37.5%). The 2-year overall survival (OS) rate was 52% for the entire series. Ultimately, 39 patients underwent allo-HSCT. The cumulative incidence of grade II-IV acute graft-versus-host disease was 33.3% (grade III-IV in 2 patients). The cumulative incidence of nonrelapse mortality was 13.2%. Among the patients who responded to nivolumab, the 2-year OS and progression-free survival (PFS) were higher in patients who underwent consolidation with allo-HSCT (77.5% versus 42.6% [P = .126] and 73.9% versus 27.2% [P = .025], respectively). Thus, the efficacy and safety of nivolumab were comparable to values reported in previous clinical trials. The percentage of patients who bridged to transplantation was high, indicating a preference for Spanish physicians. These results suggest that consolidation allo-HSCT increases OS and PFS.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Allogeneic transplantationHodgkin lymphomaNivolumabRelapsed/refractory lymphomaDisease-Free SurvivalGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHodgkin DiseaseHumansNeoplasm Recurrence, LocalNivolumabRetrospective StudiesSpainresearch article32068094open access10.1016/j.bbmt.2020.02.0031523-6536https://doi.org/10.1016/j.bbmt.2020.02.003