Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169.

Rodríguez, VíctorMartín, JesúsSarmiento-Vizcaíno, Aidade la Cruz, MercedesGarcía, Luis ABlanco, GloriaReyes, Fernando2023-01-252023-01-252018-10-25http://hdl.handle.net/10668/13136The potent antimicrobial extract of a culture of the marine derived actinomycete Streptomyces cyaneofuscatus M-169 was fractionated by reversed phase flash chromatography and preparative HPLC to yield the new Gram-positive antibiotic, anthracimycin B (1), together with its congener, anthracimycin (2). The structure of the new compound was established by analysis of its ESI-TOF MS and 1D and 2D NMR spectra, and comparison with data published for anthracimycin and anthracimycin BII-2619 (3). Notably, anthracimycin seemed to be the major and almost unique component of the extract detected by HPLC-UV-MS, making our S. cyanofuscatus strain an excellent candidate for further biosynthetic studies of this potent antibiotic.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Cantabrian SeaStreptomyces cyaneofuscatusanthracimycindeep-sea actinobacteriaAnti-Bacterial AgentsAquatic OrganismsGram-Positive BacteriaMicrobial Sensitivity TestsPhylogenyPolyketidesStreptomycesAnthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169.research article30366404open access10.3390/md161104061660-3397PMC6267485https://www.mdpi.com/1660-3397/16/11/406/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267485/pdf