Santos, CristinaGarcía-Fuentes, EduardoCallejón-Leblic, BelénGarcía-Barrera, TamaraGómez-Ariza, José LuisRayman, Margaret PVelasco, Inés2023-01-252023-01-252017-05-23http://hdl.handle.net/10668/11221The deficiency of Se, an essential micronutrient, has been implicated in adverse pregnancy outcomes. Our study was designed to determine total serum Se, selenoproteins (extracellular glutathione peroxidase (GPx-3), selenoprotein P (SeP)), selenoalbumin (SeAlb) and selenometabolites in healthy women and their newborns at delivery. This cross-sectional study included eighty-three healthy mother-baby couples. Total Se and Se species concentrations were measured in maternal and umbilical cord sera by an in-series coupling of two-dimensional size-exclusion and affinity HPLC. Additional measurements of serum SeP concentration and of serum GPx-3 enzyme activity were carried out using ELISA. Total Se concentration was significantly higher in maternal serum than in cord serum (68·9 (sd 15·2) and 56·1 (sd 14·6) µg/l, respectively; Pen2D/SE-AF-HPLC two-dimensional size-exclusion and affinity HPLCGPx-3 extracellular glutathione peroxidaseSeAlb selenoalbuminSeMetab selenometabolitesSeP selenoprotein PGestationSeleniumSelenoprotein PSelenoproteinsAdultCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleFetal BloodGlutathione PeroxidaseHumansInfant, NewbornPostpartum PeriodPregnancySeleniumSelenoproteinsYoung Adultresearch article28534447open access10.1017/S00071145170011551475-2662https://www.cambridge.org/core/services/aop-cambridge-core/content/view/CB9FFB9C9E27E06234202A572492D4A7/S0007114517001155a.pdf/div-class-title-selenium-selenoproteins-and-selenometabolites-in-mothers-and-babies-at-the-time-of-birth-div.pdf