Lopez-Pedrera, C.Aguirre-Zamorano, M. A.Munoz-Barrera, L.Sanchez-Pareja, I.Pilar, F. U.Abalos-Aguilera, M. C.Puerto, N. BarbarrojaEstevez, E. CollantesCastro, R. OrtegaPerez-Sanchez, C.2023-05-032023-05-032022-06-01Lopez-Pedrera C, Aguirre-Zamorano MÁ, Muñoz-Barrera L, Sanchez-Pareja I, Pilar FU, Ábalos-Aguilera MC, et al. POS0465 UNSUPERVISED CLUSTERING ANALYSIS OF THE SERUM PROTEOME IDENTIFIES SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS WITH DISTINCTIVE DISEASE SEVERITY AND LUPUS NEPHROPATHY. Annals Of The Rheumatic Diseases [Internet]. 23 de mayo de 2022;81(Suppl 1):486.2-4870003-4967http://hdl.handle.net/10668/20118Background: Systemic lupus erythematosus (SLE) is a remarkably heterogeneous autoimmune disease. Despite great efforts, our knowledge of serum protein patterns in severe SLE phenotypes is still limited. Objectives: This study investigated the serum proteomic profile of SLE, in order to identify relevant clinical patterns. Methods: Proximity extension immunoassay (PEA, Olink) was used to assess the serum levels of one hundred and eighty-four inflammation and organ damage-related proteins in patients with SLE (n = 72) and agematched healthy donors (HD) (n = 18). In parallel, an extensive clinical and analytical profile of recruited subjects was performed. To evaluate the contribution of molecular profiles to the disease severity, unsupervised clustering analyses were developed.enPisum sativumProteomicsLupus Erythematosus, SystemicHumansBlood ProteinsAutoimmune DiseasesPhenotypeInflammationPatient Acuityconference outputopen accessEnfermedades autoinmunesFenotipoGravedad del pacienteInflamaciónProteínas sanguíneas10.1136/annrheumdis-2022-eular.44671468-2060https://ard.bmj.com/content/annrheumdis/81/Suppl_1/486.2.full.pdf850279001401