Muñoz-Fernández, RaquelDe La Mata, ClaudiaRequena, FranciscoMartín, FranciscoFernandez-Rubio, PabloLlorca, TatianaRuiz-Magaña, Maria JoséRuiz-Ruiz, CarmenOlivares, Enrique G.2020-07-242020-07-242019-06-14Muñoz-Fernández R, De La Mata C, Requena F, Martín F, Fernandez-Rubio P, Llorca T, et al. Human predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion. Stem Cell Res Ther. 2019 Jun 14;10(1):177.http://hdl.handle.net/10668/3150Human decidual stromal cells (DSCs) are involved in the maintenance and development of pregnancy, in which they play a key role in the induction of immunological maternal-fetal tolerance. Precursors of DSCs (preDSCs) are located around the vessels, and based on their antigen phenotype, previous studies suggested a relationship between preDSCs and mesenchymal stromal/stem cells (MSCs). This work aimed to further elucidate the MSC characteristics of preDSCs.enClone cellsDeciduaImmune toleranceImmunotherapyMesenchymal stromal cellsPredecidual stromal cellsRecurrent abortionCélulas clonalesTolerancia inmunológicaInmunoterapiaCélulas madre mesenquimatosasAborto habitualMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Abortion, Spontaneous::Abortion, HabitualMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Abortion, SpontaneousMedical Subject Headings::Organisms::Eukaryota::AnimalsMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell DifferentiationMedical Subject Headings::Anatomy::Cells::Cells, CulturedMedical Subject Headings::Anatomy::Embryonic Structures::Placenta::DeciduaMedical Subject Headings::Diseases::Animal Diseases::Disease Models, AnimalMedical Subject Headings::Anatomy::Urogenital System::Genitalia::Genitalia, Female::Uterus::EndometriumMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Mesenchymal Stem Cell TransplantationMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::MiceMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancyresearch article31200769open access10.1186/s13287-019-1284-z1757-6512PMC6567662