Paris, Juan L.Vallet-Regi, Maria2022-04-282022-04-282020-06-08Paris JL, Vallet-Regí M. Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review. Pharmaceutics. 2020 Jun 8;12(6):526http://hdl.handle.net/10668/3585Mesoporous silica nanoparticles have attracted much attention in recent years as drug and gene delivery systems for biomedical applications. Among their most beneficial features for biomedicine, we can highlight their biocompatibility and their outstanding textural properties, which provide a great loading capacity for many types of cargos. In the context of cancer nanomedicine, combination therapy and gene transfection/silencing have recently been highlighted as two of its most promising fields. In this review, we aim to provide an overview of the different small molecule drug-nucleic acid co-delivery combinations that have been developed using mesoporous silica nanoparticles as carriers. By carefully selecting the chemotherapeutic drug and nucleic acid cargos to be co-delivered by mesoporous silica nanoparticles, different therapeutic goals can be achieved by overcoming resistance mechanisms, combining different cytotoxic mechanisms, or providing an additional antiangiogenic effect. The examples here presented highlight the great promise of this type of strategies for the development of future therapeutics.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Mesoporous silica nanoparticlesCo-deliveryDrug deliveryNucleic acidsGene transfectionNanomedicineMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Minerals::Silicon DioxideMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic AcidsMedical Subject Headings::Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::NanoparticlesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Delivery SystemsMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic::TransfectionMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Nanotechnology::NanomedicineMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Transfer Techniquesreview article32521800open accessNanopartículasDióxido de silicioÁcidos nucleicosEstrategias de saludTécnicas de transferencia de gen10.3390/pharmaceutics120605261999-4923PMC7356816