Montes-de-Oca-Garcia, AdrianCorral-Perez, JuanVelazquez-Diaz, DanielPerez-Bey, AlejandroRebollo-Ramos, MariaMarin-Galindo, AlbertoGomez-Gallego, FélixCalderon-Dominguez, MariaCasals, CristinaPonce-Gonzalez, Jesus G2023-05-032023-05-032022-07-04Montes-de-Oca-García A, Corral-Pérez J, Velázquez-Díaz D, Perez-Bey A, Rebollo-Ramos M, Marín-Galindo A, et al. Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults. Front Physiol. 2022 Jul 22;13:8851851664-042Xhttp://hdl.handle.net/10668/20716This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C>T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 ± 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C>T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 ± 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C>T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C>T polymorphism on the QUICKI index.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/PPARGC1ACardiometabolic riskCaucasianGenetic association studiesHealthy lifestyleMetabolismObesityPhysical exerciseSex CharacteristicsCardiorespiratory FitnessBody CompositionGenotypeAnthropometryDietPolymerase Chain ReactionAdipose Tissueresearch article35936915open accessAntropometríaCapacidad cardiovascularCaracteres sexualesComposición corporalDietaGenotipoReacción en cadena de la polimerasaTejido adiposo10.3389/fphys.2022.885185PMC9354774https://www.frontiersin.org/articles/10.3389/fphys.2022.885185/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354774/pdf