Ruiz-Limon, PatriciaMena-Vazquez, NataliaMoreno-Indias, IsabelManrique-Arija, SaraLisbona-Montañez, Jose ManuelCano-Garcia, LauraTinahones, Francisco JFernandez-Nebro, Antonio2023-05-032023-05-032022-08-06Ruiz-Limón P, Mena-Vázquez N, Moreno-Indias I, Manrique-Arija S, Lisbona-Montañez JM, Cano-García L, et al. Collinsella is associated with cumulative inflammatory burden in an established rheumatoid arthritis cohort. Biomed Pharmacother. 2022 Sep;153:113518http://hdl.handle.net/10668/22047To analyze the gut microbiota of patients with rheumatoid arthritis (RA) according to disease activity. An observational cross-sectional study of 110 patients with RA and 110 age- and sex-matched controls was performed. Patients were classified according to the disease activity (DAS28 ≥3.2 or DAS28  The mean DAS28 indicated remission/low inflammatory activity in 71 patients (64.5 %) and moderate/high activity in 39 (35.5 %) during follow-up. Alpha and beta diversity analysis revealed differences in gut microbiota between the 3 study groups. In the moderate/high activity RA, we observed a significant change in the abundance of genera compared with the other groups. The abundance of Collinsella and Bifidobacterium was increased in RA patients compared with controls. The metabolic profile of gut microbiota was characterized by differences in pathways related to Biosynthesis, Generation of Precursor Metabolites/Energy, and Degradation/Utilization/Assimilation between the 3 groups. The factors associated with cumulative inflammatory activity in RA were age (OR [95 % CI], 1.065 [1.002-1.131]), obesity (OR [95% CI], 3.829 [1.064-8.785]), HAQ score (OR [95% CI], 2.729 [1.240-5.009]), and expansion of the genus Collinsella (OR [95% CI], 3.000 [1.754-9.940]). The composition of gut microbiota differed between patients with RA and moderate/high activity, patients with remission/low activity, and controls. The genus Collinsella, age, obesity, and physical function were associated with cumulative inflammatory burden in RA.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/CollinsellaCumulative inflammatory burdenGut microbiotaInflammationRheumatoid arthritisActinobacteriaArthritis, RheumatoidCohort StudiesCross-Sectional StudiesHumansObesityRNA, Ribosomal, 16Sresearch article36076603open accessMicrobioma GastrointestinalObesidadArtritis ReumatoideEstudios TransversalesMetaboloma10.1016/j.biopha.2022.1135181950-6007https://doi.org/10.1016/j.biopha.2022.113518