Bassetti, MatteoGiacobbe, Daniele RVena, AntonioTrucchi, CeciliaAnsaldi, FilippoAntonelli, MassimoAdamkova, VaclavaAlicino, CristianoAlmyroudi, Maria-PanagiotaAtchade, EnoraAzzini, Anna MCarannante, NovellaCarnelutti, AlessiaCorcione, SilviaCortegiani, AndreaDimopoulos, GeorgeDubler, SimonGarcía-Garmendia, José LGirardis, MassimoCornely, Oliver AIanniruberto, StefanoKullberg, Bart JanLagrou, KatrienLe Bihan, ClementLuzzati, RobertoMalbrain, Manu L N GMerelli, MariaMarques, Ana JMartin-Loeches, IgnacioMesini, AlessioPaiva, José-ArturPeghin, MaddalenaRaineri, Santi MaurizioRautemaa-Richardson, RiinaSchouten, JeroenBrugnaro, PierluigiSpapen, HerbertTasioudis, PolychronisTimsit, Jean-FrançoisTisa, ValentinoTumbarello, Mariovan den Berg, Charlotte H S BVeber, BenoitVenditti, MarioVoiriot, GuillaumeWauters, JoostMontravers, Philippe2023-01-252023-01-252019-06-14http://hdl.handle.net/10668/14118The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p  The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Abdominal candidiasisCandidaCandidemiaCandidiasisICUIncidenceAgedCandidiasis, InvasiveCross InfectionEuropeFemaleHumansIncidenceIntensive Care UnitsMaleMiddle AgedOutcome Assessment, Health CareRetrospective StudiesRisk Factorsresearch article31200780open access10.1186/s13054-019-2497-31466-609XPMC6567430https://doi.org/10.1186/s13054-019-2497-3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567430/pdf