Gallardo, DavidBosch-Vizcaya, AnnaRodriguez-Romanos, RocioSantos, NazlyBuño, Ismaelde-la-Camara, RafaelBrunet, SalutJimenez-Velasco, AntonioGonzalez, MarcosNieto, Jose BMartínez-Laperche, CarolinaVallejo, CarlosFerra, ChristelleSampol, AntòniaLopez-Jimenez, JavierPerez-Simon, Jose AMartinez, CarmenDiez, Jose L2023-01-252023-01-252017-08-04Gallardo D, Bosch-Vizcaya A, Rodríguez-Romanos R, Santos N, Buño I, de la Cámara R, et al. Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches. Biol Blood Marrow Transplant. 2017 Dec;23(12):2042-2047http://hdl.handle.net/10668/11524Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor has been reported to be relevant in the appearance of acute GVHD. We explored the effect of the donor's CTLA-4 genotype in the incidence of acute GVHD associated with HA-1, HA-8, or H-Y miHA mismatches in a large cohort of 1295 patients receiving an allogeneic transplant from an HLA-identical sibling donor. The incidence of acute GVHD was higher if the donor and recipient were mismatched for HA-1, HA-8, or H-Y, but only when the donor had the CTLA-4 rs231775 AA genotype (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.27 to 3.75; P = .005; HR, 2.11, 95% CI, 1.06 to 4.18; P = .033; and HR, 1.50; 95% CI, 1.05 to 2.15; P = .025, respectively). In contrast, this increased risk of developing acute GVHD was not found when the donor presented the CTLA-4 rs231775 AG or GG genotypes. We conclude that the immune response to specific miHA mismatches is modulated by the CTLA-4 genotype of the donor.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Allogeneic transplantationCTLA-4Graft-versus-host diseaseMinor histocompatibility antigensAdolescentAdultAgedCTLA-4 AntigenChildChild, PreschoolGenotypeGraft vs Host DiseaseHistocompatibilityHumansImmunityInfantMiddle AgedMinor Histocompatibility AntigensTissue DonorsYoung Adultresearch article28827064open accessDonantes de TejidosAntígenos de Histocompatibilidad MenorAloinjertosEnfermedad Injerto contra HuéspedTrasplante de Células MadreInmunidad10.1016/j.bbmt.2017.08.0031523-6536http://www.bbmt.org/article/S1083879117306183/pdf