Manfredini, FabioLamberti, NicolaGuerzoni, FrancoNapoli, NicolaGasbarro, VincenzoZamboni, PaoloMascoli, FrancescoManfredini, RobertoBasaglia, NinoRodriguez-Borrego, Maria AuroraLopez-Soto, Pablo Jesus2023-01-252023-01-252019-02-06Manfredini F, Lamberti N, Guerzoni F, Napoli N, Gasbarro V, Zamboni P, et al. Rehabilitative Exercise Reduced the Impact of Peripheral Artery Disease on Vascular Outcomes in Elderly Patients with Claudication: A Three-Year Single Center Retrospective Study. J Clin Med. 2019 Feb 7;8(2):2102077-0383http://hdl.handle.net/10668/13538The study retrospectively evaluated the association between rehabilitative outcomes and risk of peripheral revascularizations in elderly peripheral artery disease (PAD) patients with claudication. Eight-hundred thirty-five patients were enrolled. Ankle-brachial index (ABI) and maximal walking speed (Smax) were measured at baseline and at discharge from a structured home-based rehabilitation program. For the analysis, patients were divided according to a baseline ABI value (severe: ≤0.5; moderate: ≥0.5) and according to hemodynamic or functional rehabilitative response (responder: ABI ≥0.10 and/or Smax >0.5 km/h). Three-year outcomes were collected from the regional registry. According to the inclusion criteria (age 60⁻80, ABI 0.5 km/h). Three-year outcomes were collected from the regional registry. According to the inclusion criteria (age 60⁻80, ABI < 0.80; program completion) 457 patients, 146 severe and 311 moderate, were studied. The whole population showed significant functional and hemodynamic improvements at discharge, with 56 revascularizations and 69 deaths at follow-up. Compared to the moderate group, the severe group showed a higher rate of revascularizations (17% vs. 10%, p < 0.001) and deaths (29% and 8%, respectively; p < 0.001). However, patients with severe PAD who were ABI responders after rehabilitation showed less revascularizations than non-responders (13% vs. 21%; hazard ratio (HR): 0.52) and were not different from patients with moderate disease (9%). Superimposable rates were observed for Smax responders (13% vs. 21%; HR: 0.55; moderate 10%). In conclusion, elderly patients with severe PAD empowered by better rehabilitation outcomes showed lower rates of peripheral revascularizations and deaths that were comparable to patients with moderate PADenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/ExerciseMortalityPeripheral artery diseaseRehabilitationVascular surgical proceduresAgedAnkle Brachial IndexPatient DischargeIntermittent ClaudicationPeripheral Arterial DiseaseHemodynamicsRegistriesresearch article30736443open accessAlta del pacienteClaudicación intermitenteEnfermedad arterial periféricaHemodinámicaSistema de registrosÍndice tobillo braquial10.3390/jcm8020210PMC6406499https://www.mdpi.com/2077-0383/8/2/210/pdf?version=1550484926https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406499/pdf