Jiménez-Ubieto, AnaGrande, CarlosCaballero, DoloresYáñez, LucreciaNovelli, SilvanaHernández, Miguel TManzanares, MaríaArranz, ReyesFerreiro, José JavierBobillo, SabelaMercadal, SantiagoGalego, AndreaJiménez, Javier LópezMoraleda, José MaríaVallejo, CarlosAlbo, CarmenPérez, ElenaMarrero, CarmenMagnano, LauraPalomera, LuisJarque, IsidroCoria, ErikaRodriguez, AntoniaMartín, AlejandroLópez-Guillermo, ArmandoSalar, AntonioLahuerta, Juan JoséGELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea) cooperative study group2025-01-072025-01-072017-10-26https://hdl.handle.net/10668/25019Overall survival (OS) is the gold-standard end point for studies evaluating autologous stem cell transplantation (ASCT) in follicular lymphoma (FL), but assessment may be elusive due to the lengthy disease course. We analyzed the validity of two earlier end points, proposed in the setting of first-line chemo-/immunotherapy, as surrogates for OS-progression-free survival (PFS) status at 24 months (PFS24) and complete response at 30 months (CR30) post-ASCT. We also have investigated the clinical features of patients with early progression after ASCT. Data were available for 626 chemosensitive FL patients who received ASCT between 1989 and 2007. Median follow-up was 12.2 years from ASCT. In the PFS24 analysis, 153 (24%) patients progressed within 24 months and 447 were alive and progression-free at 24 months post-ASCT (26 who died without disease progressions within 24 months were excluded). Early progression was associated with shorter OS (hazard ratio [HR], 6.8; P = 0.00001). In the subgroup of patients who received an ASCT in the setting or relapse after being exposed to rituximab, the HR was 11.3 (95% CI, 3.9-30.2; P enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Autologous Stem Cell TrasplantationCR 30Follicular LymphomaPFS 24RituximabAdolescentAdultAgedAntineoplastic AgentsDatabases, FactualDisease ProgressionDisease-Free SurvivalEndpoint DeterminationFemaleHumansImmunotherapyKaplan-Meier EstimateLymphoma, FollicularMaleMiddle AgedProportional Hazards ModelsRegistriesRetrospective StudiesRisk FactorsSpainStem Cell TransplantationTime FactorsTransplantation, AutologousTreatment OutcomeYoung Adultresearch article29076254open access10.1002/cam4.12172045-7634PMC5727300https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.1217https://pmc.ncbi.nlm.nih.gov/articles/PMC5727300/pdf