Javier Quesada-Bravo, FranciscoRocio Garcia-Carricondo, AnaEspin-Galvez, FernandoFernandez-Sanchez, CarmenFernandez-Gines, Damasodel Mar Requena-Mullor, MariaAlarcon-Rodriguez, Raquel2025-01-072025-01-072021-11-01https://hdl.handle.net/10668/24933Objectives: To compare the possible benefits of the combination of dexamethasone-bupivacaine with articaine-epinephrine as an anaesthetic block after third molar surgery. Materials and Methods: Triple-blind, randomized, controlled, parallel, phase 3 clinical trial. Two groups: experimental (93 patients) with standard anaesthetic block: 40/0.005 mg/mL articaine-epinephrine and submucosal reinforcement with 0.8 mg dexamethasone-5% bupivacaine; and control group (91 patients) with standard block: 40/0.005 mg/mL articaine-epinephrine. The surgery consisted of the extraction of the impacted mandibular third molar by performing a procedure following the same repeatable scheme. The visual analogue scale (VAS) was used to analyse postoperative pain. Results: Groups were homogeneous, without significant differences related to epidemiological variables. Postoperative pain among the first, second, and seventh postoperative days was statistically significantly lower in the experimental group compared to the control group (penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/third molar surgerybupivacainedexamethasonesubmucosapostoperative painSurgical extractionCorticosteroidsEfficacySequelaeSubmucosalAnalgesiaArticaineRemovalReliefSafetyresearch article34768600open access10.3390/jcm102150812077-0383https://www.mdpi.com/2077-0383/10/21/5081/pdf?version=1635902974719199700001