Palomar Muñoz, AzaharaCordero García, José ManuelTalavera Rubio, Mª Del PradoGarcía Vicente, Ana MªPena Pardo, Francisco JoséJiménez Londoño, Germán AndrésSoriano Castrejón, ÁngelAranda Aguilar, Enrique2023-01-252023-01-252018http://hdl.handle.net/10668/12405To assess the diagnostic accuracy of CA125, its kinetic values and positron emission tomography/computed tomography with 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG-PET/CT), in relation with tumor characteristics for suspected recurrence of ovarian cancer. To evaluate the performance of CA125-related parameters as a selection criteria to perform a [F]FDG-PET/CT.A retrospective analysis of 69 [F]FDG-PET/CT for suspected recurrence of ovarian cancer was performed. All patients had 2 measurements of CA125, before PET/CT, to calculate kinetic values, as CA125vel (CA125vel = [CA125a - CA125b]/time) and CA125dt (CA125dt = [log2 × time]/[logCA125a - CA125b]). Maximum standard uptake value (SUVmax) was calculated. The diagnostic accuracy was calculated for all the variables and the optimal cut-off value of each of them by the receiver-operating characteristics (ROC) analysis. All the tests were compared with tumor characteristics and clinical-radiological evolution during follow-up of at least 6 months.Fifty-five cases were diagnosed of recurrence (11 with CA125 enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/AgedBiomarkers, TumorCA-125 AntigenEarly Detection of CancerFemaleFluorodeoxyglucose F18HumansMiddle AgedNeoplasm Recurrence, LocalOvarian NeoplasmsPositron Emission Tomography Computed TomographyROC CurveRetrospective Studiesresearch article29702969open access10.1097/MD.00000000000100981536-5964PMC5944512https://doi.org/10.1097/md.0000000000010098https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944512/pdf