Redondo, Alba MValcárcel, DavidGonzález-Rodríguez, Ana PSuárez-Lledó, MaríaBello, José LCanales, MiguelGayoso, JorgeColorado, MercedesJarque, IsidroDel Campo, RaquelArranz, ReyesTerol, María JRifón, José JRodríguez, María JRamírez, María JCastro, NereaSánchez, AndrésLópez-Jiménez, JavierMontes-Moreno, SantiagoBriones, JavierLópez, AurelioPalomera, LuisLópez-Guillermo, ArmandoCaballero, DoloresMartín, AlejandroGrupo Español de Linfomas y Trasplante Autólogo de Médula Ósea (GELTAMO)2025-01-072025-01-072018-12-12https://hdl.handle.net/10668/25042We conducted a phase 2 trial to evaluate the safety and efficacy of bendamustine instead of BCNU (carmustine) in the BEAM (BCNU, etoposide, cytarabine and melphalan) regimen (BendaEAM) as conditioning for autologous stem-cell transplantation (ASCT) in patients with aggressive lymphomas. The primary endpoint was 3-year progression-free survival (PFS). Sixty patients (median age 55 [28-71] years) were included. All patients (except one who died early) engrafted after a median of 11 (9-72) and 14 (4-53) days to achieve neutrophil and platelet counts of >0.5 × 109 /l and >20 × 109 /l, respectively. Non-relapse mortality at 100 days and 1 year were 3.3% and 6.7%, respectively. With a median follow-up of 67 (40-77) months, the estimated 3-year PFS and overall survival (OS) were 58% and 75%, respectively. Patients in partial response at study entry had significantly worse PFS and OS than patients who underwent ASCT in complete metabolic remission, and this was the only prognostic factor associated with both PFS (Relative risk [RR], 0.27 [95% confidence interval {CI} [0.12-0.56]) and OS (RR, 0.40 [95% CI 0.17-0.97]) in the multivariate analysis. BendaEAM conditioning is therefore a feasible and effective regimen in patients with aggressive lymphomas. However, patients not in complete metabolic remission at the time of transplant had poorer survival and so should be considered for alternative treatment strategies.enBEAMaggressive lymphomasautologous stem-cell transplantationbendamustineclinical trialAdultAgedAntineoplastic Combined Chemotherapy ProtocolsAutograftsBendamustine HydrochlorideCarmustineCytarabineDisease-Free SurvivalFemaleHumansLymphomaMaleMelphalanMiddle AgedPeripheral Blood Stem Cell TransplantationPodophyllotoxinSurvival RateTransplantation Conditioningresearch article30548583open access10.1111/bjh.157131365-2141https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15713