Ramos-Petersen, LauraNester, Christopher JamesReinoso-Cobo, AndresNieto-Gil, PilarOrtega-Avila, Ana BelenGijon-Nogueron, Gabriel2022-11-082022-11-082020-12-29Ramos-Petersen L, Nester CJ, Reinoso-Cobo A, Nieto-Gil P, Ortega-Avila AB, Gijon-Nogueron G. A Systematic Review to Identify the Effects of Biologics in the Feet of Patients with Rheumatoid Arthritis. Medicina. 2020 Dec 29;57(1):231010-660Xhttp://hdl.handle.net/10668/4343Background and objective: Ninety percent of patients with rheumatoid arthritis (RA) feel foot pain during the disease process. Pharmacological treatment of RA has a systematic effect on the body and includes: Nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs (DMARDs) and biologics. The objective of our review was to examine the impact of biologics on patients with RA 'foot. Methods and material: A systematic review of randomized control trials and observational studies that evaluated the efficacy of biologics against other pharmacological treatment, and included a foot outcome measure. The search covered MEDLINE Ovid, Pubmed, CINAHL, Cochrane Library, Evidence Search, and Web of Science. Risk of bias was evaluated using Cochrane guidance and the Newcastle Ottawa Scale adapted version. Results: A total of eight studies fully met the inclusion criteria: Three randomized control trials, and five observational studies were the basis of our review. A total sample of 1856 RA patients with RA treatment participated. The use of biologics was not associated as a risk factor for post-operative surgical site infection or delayed wound healing. The benefits of biologics, in terms of the disease evolution, were assessed using X-ray. Conclusion: Evidence suggests that the use of biologics is not a risk factor for post-operative surgical site infection or delayed wound healing. The use of biologics presents benefits in terms of the disease evolution assessed through X-ray.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/BiologicsDMARDsFeetRheumatoid arthritisSystematic reviewProductos biológicosAntirreumáticosPieArtritis reumatoideRevisión sistemáticaMetaanálisisMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antirheumatic AgentsMedical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis, RheumatoidMedical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological ProductsMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Wound Infection::Surgical Wound InfectionMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Radiation::Radiation, Ionizing::X-RaysMedical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological ProductsMedical Subject Headings::Phenomena and Processes::Biological Phenomena::Biological Processes::Regeneration::Wound HealingMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk FactorsMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agentsreview article33383830Acceso abierto10.3390/medicina570100231648-9144PMC7824565