García de Guadiana-Romualdo, LuisMorell-García, DanielFavaloro, Emmanuel JVílchez, Juan ABauça, Josep MAlcaide Martín, María JGutiérrez Garcia, Irenede la Hera Cagigal, PatriciaEgea-Caparrós, José ManuelPérez Sanmartín, SoniaGutiérrez Revilla, José IUrrechaga, EloísaÁlamo, Jose MHernando Holgado, Ana MLorenzo-Lozano, María-CarmenCanalda Campás, MagdalenaJuncos Tobarra, María AMorales-Indiano, CristianVírseda Chamorro, IsabelPastor Murcia, YolandaSahuquillo Frías, LauraAltimira Queral, LauraNuez-Zaragoza, ElisaAdell Ruiz de León, JuanRuiz Ripa, AliciaSalas Gómez-Pablos, PalomaCebreiros López, IriaFernández Uriarte, AmaiaLarruzea, AlexLópez Yepes, María LSancho-Rodríguez, NataliaZamorano Andrés, María CPedregosa Díaz, JoséSáenz, LuisEsparza Del Valle, ClaraBaamonde Calzada, María CGarcía Muñoz, SaraVera, MarinaMartín Torres, EstherSánchez Fdez-Pacheco, SilviaVicente Gutiérrez, LuisJiménez Añón, LauraPérez Martínez, AlfonsoPons Castillo, AurelioGonzález Tamayo, RuthFérriz Vivancos, JorgeRodríguez-Fraga, OlaiaDíaz-Brito, VicensAguadero, VicenteGarcía Arévalo, M GArnaldos Carrillo, MaríaGonzález Morales, MercedesNúñez Gárate, MaríaRuiz Iruela, CristinaEsteban Torrella, PatriciaVila Pérez, MartíAcevedo Alcaraz, CristinaBlázquez-Manzanera, Alfonso LGalán Ortega, Amparo2025-01-072025-01-072021-07-16https://hdl.handle.net/10668/27050Coagulopathy is a key feature of COVID-19 and D-dimer has been reported as a predictor of severity. However, because D-dimer test results vary considerably among assays, resolving harmonization issues is fundamental to translate findings into clinical practice. In this retrospective multicenter study (BIOCOVID study), we aimed to analyze the value of harmonized D-dimer levels upon admission for the prediction of in-hospital mortality in COVID-19 patients. All-cause in-hospital mortality was defined as endpoint. For harmonization of D-dimer levels, we designed a model based on the transformation of method-specific regression lines to a reference regression line. The ability of D-dimer for prediction of death was explored by receiver operating characteristic curves analysis and the association with the endpoint by Cox regression analysis. Study population included 2663 patients. In-hospital mortality rate was 14.3%. Harmonized D-dimer upon admission yielded an area under the curve of 0.66, with an optimal cut-off value of 0.945 mg/L FEU. Patients with harmonized D-dimer ≥ 0.945 mg/L FEU had a higher mortality rate (22.4% vs. 9.2%; p enCOVID-19D-dimerHarmonizationMortalityPrognosisBiomarkersCOVID-19Fibrin Fibrinogen Degradation ProductsHumansPrognosisRegistriesRetrospective StudiesSeverity of Illness IndexSpainresearch article34272635open access10.1007/s11239-021-02527-y1573-742XPMC8284690https://link.springer.com/content/pdf/10.1007/s11239-021-02527-y.pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8284690/pdf