Ashofteh Yazdi, A.Melchor, J.Torres, J.Faris, I.Callejas, A.Gonzalez-Andrades, M.Rus, G.2022-03-312022-03-312020-07-14Ashofteh Yazdi A, Melchor J, Torres J, Faris I, Callejas A, Gonzalez-Andrades M, et al. Characterization of non-linear mechanical behavior of the cornea. Sci Rep. 2020 Jul 14;10(1):11549.http://hdl.handle.net/10668/3510The objective of this study was to evaluate which hyperelastic model could best describe the non-linear mechanical behavior of the cornea, in order to characterize the capability of the non-linear model parameters to discriminate structural changes in a damaged cornea. Porcine corneas were used, establishing two different groups: control (non-treated) and NaOH-treated (damaged) corneas (n = 8). NaOH causes a chemical burn to the corneal tissue, simulating a disease associated to structural damage of the stromal layer. Quasi-static uniaxial tensile tests were performed in nasal-temporal direction immediately after preparing corneal strips from the two groups. Three non-linear hyperelastic models (i.e. Hamilton-Zabolotskaya model, Ogden model and Mooney-Rivlin model) were fitted to the stress-strain curves obtained in the tensile tests and statistically compared. The corneas from the two groups showed a non-linear mechanical behavior that was best described by the Hamilton-Zabolotskaya model, obtaining the highest coefficient of determination (R2 > 0.95). Moreover, Hamilton-Zabolotskaya model showed the highest discriminative capability of the non-linear model parameter (Parameter A) for the tissue structural changes between the two sample groups (p = 0.0005). The present work determines the best hyperelastic model with the highest discriminative capability in description of the non-linear mechanical behavior of the cornea.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/AnimalsBiomechanical PhenomenaNonlinear DynamicsSwineCorneaAnimalesFenómenos biomecánicosDinámicas no linealesPorcinosCórneaMedical Subject Headings::Organisms::Eukaryota::AnimalsMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Optical Phenomena::AnisotropyMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Biomechanical PhenomenaMedical Subject Headings::Anatomy::Sense Organs::Eye::Anterior Eye Segment::CorneaMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::ElasticityMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Nonlinear DynamicsMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Hydroxides::Sodium HydroxideMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Mechanical Processes::Stress, MechanicalMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::SwineMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Tensile StrengthMedical Subject Headings::Diseases::Wounds and Injuries::Burns::Burns, Chemicalresearch article32665558open access10.1038/s41598-020-68391-72045-2322PMC7360609