Rueda-Robles, AscensiónRubio-Tomás, TeresaPlaza-Diaz, JulioÁlvarez-Mercado, Ana I.2022-09-202022-09-202021-07-10Rueda-Robles A, Rubio-Tomás T, Plaza-Diaz J, Álvarez-Mercado AI. Impact of Dietary Patterns on H. pylori Infection and the Modulation of Microbiota to Counteract Its Effect. A Narrative Review. Pathogens. 2021 Jul 10;10(7):875.http://hdl.handle.net/10668/4075Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the stomach and can induce gastric disease and intra-gastric lesions, including chronic gastritis, peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. This bacterium is responsible for long-term complications of gastric disease. The conjunction of host genetics, immune response, bacterial virulence expression, diet, micronutrient availability, and microbiome structure influence the disease outcomes related to chronic H. pylori infection. In this regard, the consumption of unhealthy and unbalanced diets can induce microbial dysbiosis, which infection with H. pylori may contribute to. However, to date, clinical trials have reported controversial results and current knowledge in this field is inconclusive. Here, we review preclinical studies concerning the changes produced in the microbiota that may be related to H. pylori infection, as well as the involvement of diet. We summarize and discuss the last approaches based on the modulation of the microbiota to improve the negative impact of H. pylori infection and their potential translation from bench to bedside.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Helicobacter pyloriDietGastrointestinal microbiotaExperimental modelsTherapeutic approachesDysbiosisPeptic ulcerDietaMicrobioma gastrointestinalModelos teóricosConductas terapéuticasDisbiosisGastritisÚlcera pépticaMedical Subject Headings::Organisms::Bacteria::Proteobacteria::Epsilonproteobacteria::Helicobacter::Helicobacter pyloriMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, B-Cell::Lymphoma, B-Cell, Marginal ZoneMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::VirulenceMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::DysbiosisMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::GastritisMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Stomach DiseasesMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::AdenocarcinomaMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::MicrobiotaMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::DietMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::ImmunityMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::MicronutrientsMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Peptic Ulcerreview article34358024open access10.3390/pathogens100708752076-0817PMC8308520