Linares-Gonzalez, LauraRodenas-Herranz, TeresaCampos, FernandoRuiz-Villaverde, RicardoCarriel, Víctor2022-09-222022-09-222021-09-30Linares-Gonzalez L, Rodenas-Herranz T, Campos F, Ruiz-Villaverde R, Carriel V. Basic Quality Controls Used in Skin Tissue Engineering. Life . 2021 Sep 30;11(10):1033http://hdl.handle.net/10668/4102Reconstruction of skin defects is often a challenging effort due to the currently limited reconstructive options. In this sense, tissue engineering has emerged as a possible alternative to replace or repair diseased or damaged tissues from the patient's own cells. A substantial number of tissue-engineered skin substitutes (TESSs) have been conceived and evaluated in vitro and in vivo showing promising results in the preclinical stage. However, only a few constructs have been used in the clinic. The lack of standardization in evaluation methods employed may in part be responsible for this discrepancy. This review covers the most well-known and up-to-date methods for evaluating the optimization of new TESSs and orientative guidelines for the evaluation of TESSs are proposed.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Skin tissue engineeringQuality controlHistological techniquesBiochemical methodsBiomechanical evaluationEnfermedades de la piel y tejido conjuntivoControl de calidadTécnicas histológicasFenómenos bioquímicosReacciones bioquímicasMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Culture Techniques::Cell Engineering::Tissue EngineeringMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Surgical Equipment::Artificial Organs::Skin, ArtificialMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Weights and Measures::Reference StandardsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Biomedical and Dental Materials::Biocompatible MaterialsMedical Subject Headings::Phenomena and Processes::Biological Phenomena::Biological Processes::Regeneration::Wound Healingreview article34685402open access10.3390/life111010332075-1729PMC8541591