Escrihuela-Vidal, FrancescLopez-Cortes, Luis EduardoEscola-Verge, LauraDe-Alarcon-Gonzalez, AristidesCuervo, GuillermoSanchez-Porto, AntonioFernandez-Hidalgo, NuriaLuque, RafaelMontejo, MiguelMiro, Jose MGoenaga, Miguel AngelMuñoz, PatriciaValerio, MaricelaRipa, MarcoSousa-Regueiro, DoloresGurgui MerceFariñas-Alvarez, Maria CarmenMateu, LourdesGarcia Vazquez, ElisaGalvez-Acebal, JuanCarratala, Jordi2025-01-072025-01-072021-03-29Escrihuela-Vidal F, López-Cortés LE, Escolà-Vergé L, De Alarcón González A, Cuervo G, Sánchez-Porto A, et al. Clinical Features and Outcomes of Streptococcus anginosus Group Infective Endocarditis: A Multicenter Matched Cohort Study. Open Forum Infect Dis. 2021 Mar 29;8(6):ofab163.2328-8957https://hdl.handle.net/10668/27759Although Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption. We performed a retrospective analysis of prospectively collected data from consecutive patients with definite SAG endocarditis in 28 centers in Spain and Italy. A comparison between cases due to SAG endocarditis and viridans group streptococci (VGS) or Streptococcus gallolyticus group (SGG) was performed in a 1:2 matched analysis. Of 5336 consecutive cases of definite endocarditis, 72 (1.4%) were due to SAG and matched with 144 cases due to VGS/SGG. SAG endocarditis was community acquired in 64 (88.9%) cases and affected aortic native valve in 29 (40.3%). When comparing SAG and VGS/SGG endocarditis, no significant differences were found in septic shock (8.3% vs 3.5%, P = .116); valve disorder, including perforation (22.2% vs 18.1%, P = .584), pseudoaneurysm (16.7% vs 8.3%, P = .108), or prosthesis dehiscence (1.4% vs 6.3%, P = .170); paravalvular complications, including abscess (25% vs 18.8%, P = .264) and intracardiac fistula (5.6% vs 3.5%, P = .485); heart failure (34.7% vs 38.9%, P = .655); or embolic events (41.7% vs 32.6%, P = .248). Indications for surgery (70.8% vs 70.8%; P = 1) and mortality (13.9% vs 16.7%; P = .741) were similar between groups. SAG endocarditis is an infrequent but serious condition that presents a prognosis similar to that of VGS/SGG.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Streptococcus anginosusStreptococcus gallolyticusinfective endocarditisviridans group streptococciStreptococcus anginosusShock, SepticAbscessRetrospective StudiesAneurysm, FalseAortic ValveEndocarditisHeart FailureProstheses and ImplantsPrognosisStreptococcus gallolyticusresearch article34189163open accessEndocarditisAbscesoPrótesis e implantesInsuficiencia cardíacaFístulaPacientesStreptococcus anginosusAneurisma falsoStreptococcus gallolyticus10.1093/ofid/ofab163PMC8231368https://academic.oup.com/ofid/article-pdf/8/6/ofab163/38825232/ofab163.pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8231368/pdf