de-Dios-Caballero, Juandel-Campo, RosaRoyuela, AnaSole, AmparoMaiz, LuisOlveira, CasildaQuintana-Gallego, Estherde-Gracia, JavierCobo, MartaGomez-de-la-Pedrosa, EliaOliver, AntonioCanton, RafaelSole, AmparoCortell, IsidoroAsensio, OscarGarcia, GloriaMartinez, Maria TeresaCols, MariaSalcedo, AntonioVazquez, CarlosBaranda, FelixGiron, RosaQuintana, EstherDelgado, Isabelde-Miguel, Maria AngelesGarcia, MartaOliva, ConcepcionPrados, Maria ConcepcionBarrio, Maria IsabelPastor, Maria DoloresOlveira, Casildade-Gracia, JavierAlvarez, AntonioEscribano, AmparoCastillo, SilviaFiguerola, JoanTogores, BernatOliver, AntonioLopez, Carlade-Dios-Caballero, JuanTato, MartaMaiz, LuisSuarez, LucreciaCanton, Rafael2023-02-122023-02-122015-09-281569-1993http://hdl.handle.net/10668/18811Background: Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented.Methods: 24 CF-Units for adult (n = 12) and pediatric (n = 12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed.Results: 341 patients [mean (SD) age 21 (11) years, 180 >= 18 years, mean (SD) FEV1 = 68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p = 18 years, mean (SD) FEV1 = 68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (pb 0.001 and p = 0.003, respectively). Conclusions: The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain.enCystic fibrosisPulmonary infection-colonizationRespiratory pathogensP. aeruginosaResistant staphylococcus-aureusAntimicrobial susceptibilitySpainEpidemiologyMicrobiologyPreventionMethicillin-Resistant Staphylococcus aureusPseudomonas aeruginosaSpainCystic FibrosisPrevalencePseudomonas Infectionsresearch articleRestricted AccessPseudomonas aeruginosaMicrobiologíaStaphylococcus aureus Resistente a MeticilinaSistema de RegistrosEstudio MulticéntricoFibrosis Quística10.1016/j.jcf.2015.09.0041873-5010http://www.cysticfibrosisjournal.com/article/S156919931500212X/pdf377728800014