Chamandi, ChekrallahBarbanti, MarcoMunoz-Garcia, AntonioLatib, AzeemNombela-Franco, LuisGutiérrez-Ibanez, EnriqueVeiga-Fernandez, GabrielaCheema, Asim NCruz-Gonzalez, IgnacioSerra, VicençTamburino, CorradoMangieri, AntonioColombo, AntonioJiménez-Quevedo, PilarElizaga, JaimeLee, Dae-HyunGarcia Del Blanco, BrunoPuri, RishiCôté, MélaniePhilippon, FrançoisRodés-Cabau, Josep2023-01-252023-01-252019-05-22http://hdl.handle.net/10668/14021The aim of this study was to determine the impact of new-onset persistent (NOP) left bundle branch block (LBBB) on long-term (>2 year) outcomes after transcatheter aortic valve replacement (TAVR). The impact of NOP-LBBB after TAVR remains controversial and no data exist regarding long-term outcomes. A total of 1,020 consecutive patients without pre-existing LBBB or permanent pacemaker implantation (PPI) undergoing TAVR were included. NOP-LBBB was defined as any new LBBB post-TAVR that persisted at hospital discharge. Follow-up clinical and echocardiographic data were obtained at a median of 3 years (interquartile range: 2 to 5 years) post-TAVR. NOP-LBBB occurred in 212 patients (20.1%) following TAVR. There were no differences between NOP-LBBB and no NOP-LBBB groups, except for a higher use of the self-expandable CoreValve system in the NOP-LBBB group (p  After a median follow-up of 3 years post-TAVR, NOP-LBBB was not associated with a higher mortality or heart failure rehospitalization. However, NOP-LBBB increased the risk of permanent pacemaker implantation and negatively impacted left ventricular function over time. These results should inform future efforts for improving the management of patients with NOP-LBBB post-TAVR.enleft bundle branch blockleft ventricular ejection fractionlong-term outcomespacemakertranscatheter aortic valve replacementAgedAged, 80 and overBundle-Branch BlockCardiac Pacing, ArtificialCause of DeathDisease ProgressionFemaleHeart FailureHumansMalePatient ReadmissionRetrospective StudiesRisk AssessmentRisk FactorsSpainStroke VolumeTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeVentricular Function, Leftresearch article31129090open access10.1016/j.jcin.2019.03.0251876-7605https://doi.org/10.1016/j.jcin.2019.03.025