Díez, CristinaDel Romero-Raposo, JorgeMican, RafaelLópez, Juan CBlanco, José RCalzado, SoniaSamperiz, GloriaPortilla, JoaquínGarcía-Fraile, Lucio JGutiérrez, FélixGómez-Sirvent, Juan LSuárez-García, InésAmador, ConchaNovella, MaríaArribas, Jose RMoreno, SantiagoGonzález-García, JuanJarrín, InmaculadaBerenguer, Juanfor CoRIS2025-01-072025-01-072021-07-29https://hdl.handle.net/10668/28114We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/COVID-19CoronavirusHIVSARS-CoV-2AdolescentAdrenal Cortex HormonesAdultAgedAged, 80 and overAnti-HIV AgentsCD4 Lymphocyte CountCOVID-19ChildChild, PreschoolDrug UsersFemaleHIV InfectionsHospitalizationHumansInfantInfant, NewbornMaleMiddle AgedRetrospective StudiesSpainYoung AdultCOVID-19 Drug Treatmentresearch article34324783open access10.1111/hiv.131451468-1293PMC8444663https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hiv.13145https://pmc.ncbi.nlm.nih.gov/articles/PMC8444663/pdf