Adherence to nutrition-based cancer prevention guidelines and breast, prostate and colorectal cancer risk in the MCC-Spain case-control study.

Romaguera, DoraGracia-Lavedan, EstherMolinuevo, Amaiade Batlle, JordiMendez, MichelleMoreno, VictorVidal, CarmenCastelló, AdelaPérez-Gómez, BeatrizMartín, VicenteMolina, Antonio JDávila-Batista, VerónicaDierssen-Sotos, TrinidadGómez-Acebo, InésLlorca, JavierGuevara, MarcelaCastilla, JesúsUrtiaga, CarmenLlorens-Ivorra, CristóbalFernández-Tardón, GuillermoTardón, AdoninaLorca, José AndrésMarcos-Gragera, RafaelHuerta, José MaríaOlmedo-Requena, RocíoJimenez-Moleon, José JuanAltzibar, Jonede Sanjosé, SilviaPollán, MarinaAragonés, NúriaCastaño-Vinyals, GemmaKogevinas, ManolisAmiano, Pilar2023-01-252023-01-252017-04-21http://hdl.handle.net/10668/11059Prostate, breast and colorectal cancer are the most common tumours in Spain. The aim of the present study was to evaluate the association between adherence to nutrition-based guidelines for cancer prevention and prostate, breast and colorectal cancer, in the MCC-Spain case-control study. A total of 1,718 colorectal, 1,343 breast and 864 prostate cancer cases and 3,431 population-based controls recruited between 2007 and 2012, were included in the present study. The World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) score based on six recommendations for cancer prevention (on body fatness, physical activity, foods and drinks that promote weight gain, plant foods, animal foods and alcoholic drinks; score range 0-6) was constructed. We used unconditional logistic regression analysis adjusting for potential confounders. One-point increment in the WCRF/AICR score was associated with 25% (95% CI 19-30%) lower risk of colorectal, and 15% (95% CI 7-22%) lower risk of breast cancer; no association with prostate cancer was detected, except for cases with a Gleason score ≥7 (poorly differentiated/undifferentiated tumours) (OR 0.87, 95% CI 0.76-0.99). These results add to the wealth of evidence indicating that a great proportion of common cancer cases could be avoided by adopting healthy lifestyle habits.enbreast cancercase-control studycolorectal cancernutrition-based guidelinesprostate cancerBreast NeoplasmsColorectal NeoplasmsFemaleHumansLife StyleMaleNutrition TherapyProstatic NeoplasmsRisk FactorsSpainAdherence to nutrition-based cancer prevention guidelines and breast, prostate and colorectal cancer risk in the MCC-Spain case-control study.research article28380695open access10.1002/ijc.307221097-0215https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.30722