Pinto-Medel, Maria JesusOliver-Martos, BegoñaUrbaneja-Romero, PatriciaHurtado-Guerrero, IsaacOrtega-Pinazo, JesusSerrano-Castro, PedroFernandez, OscarLeyva, Laura2023-01-252023-01-252017-08-18Pinto-Medel MJ, Oliver-Martos B, Urbaneja-Romero P, Hurtado-Guerrero I, Ortega-Pinazo J, Serrano-Castro P, et al. Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment. Sci Rep. 2017 Aug 18;7(1):8727http://hdl.handle.net/10668/11520The alteration of DNA methylation patterns are a key component of disease onset and/or progression. Our objective was to evaluate the differences in Long Interspersed Nuclear Element-1 (LINE-1) methylation levels, as a surrogate marker of global DNA methylation, between multiple sclerosis (MS) patients and healthy controls. In addition, we assessed the association of LINE-1 methylation with clinical disease activity in patients treated with IFNbeta (IFNβ). We found that individuals with high levels of LINE-1 methylation showed 6-fold increased risk of suffering MS. Additionally, treated MS patients who bear high LINE-1 methylation levels had an 11-fold increased risk of clinical activity. Moreover, a negative correlation between treatment duration and percentage of LINE-1 methylation, that was statistically significant exclusively in the group of patients without clinical activity, was observed. Our data suggest that in MS patients, a slight global DNA hypermethylation occurs that may be related to the pathophysiology of the disease. In addition, global DNA methylation levels could play a role as a biomarker for the differential clinical response to IFNβ.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Multiple SclerosisMultivariate AnalysisROC CurveReference StandardsAdultCase-Control StudiesDNA MethylationDisease SusceptibilityFemaleHumansInterferon-betaLogistic ModelsLong Interspersed Nucleotide ElementsMaleresearch article28821874open accessMetilaciónDuración de la TerapiaElementos QuímicosEsclerosis MúltipleJuego e Implementos de Juego10.1038/s41598-017-09301-22045-2322PMC5562733https://www.nature.com/articles/s41598-017-09301-2.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562733/pdf