Cosío, Borja GPascual-Guardia, SergiBorras-Santos, AliciaPeces-Barba, GermánSantos, SaludVigil, LauraSoler-Cataluña, Juan JoséMartínez-González, CristinaCasanova, CiroMarcos, Pedro JAlvarez, Carlos JLópez-Campos, José LuisGea, JoaquimGarcia-Aymerich, JudithMolina, JesúsRomán, MiguelMoises, JorgeSzabo, ViktoriaReagan, Elizabeth ASan José Estépar, RaúlWashko, GeorgeAgustí, AlvarFaner, Rosa2025-01-072025-01-072020-10-052312-0541https://hdl.handle.net/10668/27811The phenotypic characteristics of chronic obstructive pulmonary disease (COPD) in individuals younger than 50 years of age (early COPD) are not well defined. This prospective, multicentre, case-control study sought to describe these characteristics and compare them with those of smokers (≥10 pack-years) of similar age with normal spirometry (controls). We studied 92 cases (post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC)enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/research article33043045open access10.1183/23120541.00047-2020PMC7533304https://openres.ersjournals.com/content/erjor/6/4/00047-2020.full.pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7533304/pdf