Vega-García, NTorrebadell, MJiménez-Velasco, AOrtega, MAbad, LPratcorona, MMuñoz, LMalatesta, RCalvente, LCatalà, ABerrueco, RRuiz-Llobet, AEstella, CTrabazo, MAlonso-Saladrigues, AMesegué, MPascual, ALassaletta, ÁBadell, IPisa, SVelasco, MRDapena, JLRives, SRamirez-Orellana, MCamós, M2016-09-292016-09-292016-06Vega-García N, Torrebadell M, Jiménez-Velasco A; Ortega M, Abad L, Pratcorona M, et al. Risk factors in pediatric T-cell acute lymphoblastic leukemia: a collaborative study of the biological committee of the leukemia group of the Spanish Hematology and Oncology Pediatric Society. Haematologica. 2016; 101 (s1) E870.0390-6078http://hdl.handle.net/10668/2435Background: Useful biomarkers for risk stratification in pediatric T-ALL are still needed. Several biological variables have been proposed as new prognostic biomarkers, including NOTCH1, FBXW7, PTEN & RAS mutations, expression of myeloid antigens and presence of copy number alterations (CNAs) of certain genes, but published results are controversial. Aims: To analyze the prognostic impact of mutations, CNAs and myeloid antigens expression in a series of 56 pediatric T-ALL patients.enBiomarcadoresProteínas del ciclo celularNiñoProteínas F-boxHumanosMutaciónLeucemia-linfoma linfoblástico de células T precursorasUbicuitina-proteína ligasasMedical Subject Headings::Chemicals and Drugs::Biological Factors::BiomarkersMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Cell Cycle ProteinsMedical Subject Headings::Named Groups::Persons::Age Groups::ChildMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::F-Box ProteinsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::MutationMedical Subject Headings::Diseases::Immune System Diseases::Immunoproliferative Disorders::Lymphoproliferative Disorders::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma::Precursor T-Cell Lymphoblastic Leukemia-LymphomaMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Ligases::Ubiquitin-Protein Ligase Complexes::Ubiquitin-Protein Ligasesconference presentationopen access1592-8721