González-Domínguez, RaúlGonzález-Domínguez, ÁlvaroSayago, AnaGonzález-Sanz, Juan DiegoLechuga-Sancho, Alfonso MaríaFernández-Recamales, Ángeles2023-01-182023-01-182021-03-14González-Domínguez R, González-Domínguez Á, Sayago A, González-Sanz JD, Lechuga-Sancho AM, Fernández-Recamales Á. Mechanistic Insights into Alzheimer's Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways. Biomedicines. 2021 Mar 14;9(3):298http://hdl.handle.net/10668/4595Hydrophilic metabolites are closely involved in multiple primary metabolic pathways and, consequently, play an essential role in the onset and progression of multifactorial human disorders, such as Alzheimer's disease. This review article provides a comprehensive revision of the literature published on the use of mass spectrometry-based metabolomics platforms for approaching the central metabolome in Alzheimer's disease research, including direct mass spectrometry, gas chromatography-mass spectrometry, hydrophilic interaction liquid chromatography-mass spectrometry, and capillary electrophoresis-mass spectrometry. Overall, mounting evidence points to profound disturbances that affect a multitude of central metabolic pathways, such as the energy-related metabolism, the urea cycle, the homeostasis of amino acids, fatty acids and nucleotides, neurotransmission, and others.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Central metabolitesAlzheimer’s diseaseMass spectrometryCentral metabolic pathwaysEnfermedad de AlzheimerEspectrometría de masasRedes y vías metabólicasMetabolómicaHomeostasisMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino AcidsMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::NucleotidesMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty AcidsMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::MetabolomeMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::HomeostasisMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction::Synaptic TransmissionMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::UreaMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass SpectrometryMedical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseasesreview article33799385open access10.3390/biomedicines90302982227-9059PMC7998757