Becerra-Muñoz, Víctor ManuelNúñez-Gil, Iván JEid, Charbel MarounGarcía Aguado, MarcosRomero, RodolfoHuang, JiaMulet, AlbaUgo, FabrizioRametta, FrancescoLiebetrau, ChristophAparisi, AlvaroFernández-Rozas, InmaculadaViana-Llamas, María CFeltes, GiselaPepe, MartinoMoreno-Rondón, Luis ACerrato, EnricoRaposeiras-Roubín, SergioAlfonso, EmilioCarrero-Fernández, AnaBuzón-Martín, LuisAbumayyaleh, MohammadGonzalez, AdelinaFernández Ortiz, AntonioMacaya, CarlosEstrada, VicenteFernández-Pérez, CristinaGómez-Doblas, Juan José2023-02-092023-02-092021http://hdl.handle.net/10668/16618the coronavirus disease 2019 (COVID-19) is characterized by poor outcomes and mortality, particularly in older patients. post hoc analysis of the international, multicentre, 'real-world' HOPE COVID-19 registry. All patients aged ≥65 years hospitalised for COVID-19 were selected. Epidemiological, clinical, analytical and outcome data were obtained. A comparative study between two age subgroups, 65-74 and ≥75 years, was performed. The primary endpoint was all cause in-hospital mortality. about, 1,520 patients aged ≥65 years (60.3% male, median age of 76 [IQR 71-83] years) were included. Comorbidities such as hypertension (69.2%), dyslipidaemia (48.6%), cardiovascular diseases (any chronic heart disease in 38.4% and cerebrovascular disease in 12.5%), and chronic lung disease (25.3%) were prevalent, and 49.6% were on ACEI/ARBs. Patients aged 75 years and older suffered more in-hospital complications (respiratory failure, heart failure, renal failure, sepsis) and a significantly higher mortality (18.4 vs. 48.2%, P 1 (OR 8.31) to be independent predictors of mortality. patients aged ≥65 years hospitalised for COVID-19 had high rates of in-hospital complications and mortality, especially among patients 75 years or older. Age ≥75 years, dementia, peripheral oxygen saturation 1 were independent predictors of mortality in this population.enCoronavirus disease 2019SARS-CoV-2comorbiditiesolder adultsAgedAged, 80 and overCOVID-19FemaleGeriatric AssessmentHospital MortalityHospitalizationHumansIntensive Care UnitsInternational CooperationMaleMortalityMultimorbidityPrognosisRegistriesRisk AssessmentRisk FactorsSARS-CoV-2research article33201181open access10.1093/ageing/afaa2581468-2834PMC7717146https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717146https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717146/pdf