Frühbeck, GemaBalaguer, InmaculadaMendez-Gimenez, LeireValenti, VíctorBecerril, SaraCatalan, VictoriaGomez-Ambrosi, JavierSilva, CamiloSalvador, JavierCalamita, GiuseppeMalagon, Maria MRodriguez, Amaia2023-02-092023-02-092020-05-31Frühbeck G, Balaguer I, Méndez-Giménez L, Valentí V, Becerril S, Catalán V, et al. Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation. Cells. 2020 Jun 4;9(6):1403.http://hdl.handle.net/10668/15701Aquaporin-11 (AQP11) is expressed in human adipocytes, but its functional role remains unknown. Since AQP11 is an endoplasmic reticulum (ER)-resident protein that transports water, glycerol, and hydrogen peroxide (H2O2), we hypothesized that this superaquaporin is involved in ER stress induced by lipotoxicity and inflammation in human obesity. AQP11 expression was assessed in 67 paired visceral and subcutaneous adipose tissue samples obtained from patients with morbid obesity and normal-weight individuals. We found that obesity and obesity-associated type 2 diabetes increased (penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/aquaporinsendoplasmic reticulum stressobesityAdipocytesAdultAquaporinsCell DifferentiationDiabetes Mellitus, Type 2Endoplasmic Reticulum StressFemaleGene SilencingHumansInflammationIntra-Abdominal FatLipolysisMaleMiddle AgedModels, BiologicalObesityTransforming Growth Factor beta1Tumor Necrosis Factor-alphaUp-Regulationresearch article32512939open accessAcuaporinasAdipocitosDiabetes Mellitus tipo 2Diferenciación celularEstrés del retículo endoplásmicoFactor de vecrosis tumoral alfaGrasa intraabdominalInflamaciónLipólisisObesidadRegulación hacia arribaSilenciador del gen10.3390/cells90614032073-4409PMC7349025https://www.mdpi.com/2073-4409/9/6/1403/pdf?version=1591959733https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349025/pdf