Romero-Gómez, BenjamínGuerrero-Alonso, PaulaCarmona-Torres, Juan ManuelPozuelo-Carrascosa, Diana PLaredo-Aguilera, José AlbertoCobo-Cuenca, Ana Isabel2025-01-072025-01-072020-11-272077-0383https://hdl.handle.net/10668/28229The use of levothyroxine is not always related to the elimination of the symptoms of hypothyroidism. The aim of this study is to compare the health-related quality of life (HRQOL) of a group of hypothyroid women under levothyroxine treatment with that of a group of non-hypothyroid women. A case-control study was performed. We used convenience sampling. The case group consisted of 152 levothyroxine-treated hypothyroid women; the control group consisted of 238 women without hypothyroidism disorders. All of the participants were euthyroid according to the clinical practice guidelines. We used as instruments the Short Form-12 questionnaire (SF-12v1) and a sociodemographic questionnaire. Hypothyroid women scored significantly lower in HRQOL in SF-12v1 mental and physical components than the control group (mental component summary: 41.23 ± 12.12 vs. 46.45 ± 10.22, p Despite being euthyroid, women with hypothyroidism showed a poorer quality of life than women without hypothyroidism. Health professionals need to assess the HRQOL of women with hypothyroidism. Further research on HRQOL and hypothyroidism is needed.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/healthhypothyroidismquality of lifethyroid hormonewomenresearch article33261144open access10.3390/jcm9123864PMC7761108https://www.mdpi.com/2077-0383/9/12/3864/pdf?version=1606794960https://pmc.ncbi.nlm.nih.gov/articles/PMC7761108/pdf