Gayoso, JBalsalobre, PPascual, M JCastilla-Llorente, CLopez-Corral, LKwon, MSerrano, DPiñana, J LHerrera, PFerra, CPascual, CHeras, IMontesinos, PZabalza, ABento, LFiguera, ABuño, IDiez-Martin, J L2023-01-252023-01-252016-05-09Gayoso J, Balsalobre P, Pascual MJ, Castilla-Llorente C, López-Corral L, Kwon M, et al. Busulfan-based reduced intensity conditioning regimens for haploidentical transplantation in relapsed/refractory Hodgkin lymphoma: Spanish multicenter experience. Bone Marrow Transplant. 2016 Oct;51(10):1307-1312http://hdl.handle.net/10668/10067Relapsed or refractory Hodgkin lymphoma (advanced HL) still remains a therapeutic challenge. Recently, unmanipulated haploidentical related donor transplant with reduced conditioning regimen (HAPLO-RIC) and post-transplant cyclophosphamide (PT-Cy) as GvHD prophylaxis has became a promising rescue strategy potentially available to almost every patient. This paper reports our multicenter experience using an IV busulfan-based HAPLO-RIC regimen and PT-Cy in the treatment of 43 patients with advanced HL. Engraftment occurred in 42 patients (97.5%), with a median time to neutrophil and platelet recovery of 18 and 26 days. Cumulative incidences of grades II-IV acute GvHD and chronic GvHD were 39% and 19%, respectively. With a median follow-up of 25.5 months for survivors, 27 patients are alive, with 22 of them disease free. Cumulative incidences of 1-year non-relapse mortality and relapse at 2 years were 21% and 24%, respectively. The estimated 2-year event-free survival (EFS) and overall survival (OS) were 48% and 58%, respectively. CR prior to HAPLO-RIC correlated with better EFS (78.5% vs 33.5%; P=0.015) and OS (86% vs 46%; P=0.044). Our findings further confirm prior reports using HAPLO-RIC in advanced HL in a multicenter approach employing an IV busulfan-based conditioning regimen.enSpainSurvival AnalysisTransplantation ConditioningTransplantation, HaploidenticalYoung AdultAdolescentAdultBusulfanCyclophosphamideFemaleGraft vs Host DiseaseHodgkin DiseaseHumansMaleMiddle AgedSalvage Therapyresearch article27159177Restricted AccessBusulfanoTrasplantesInforme de InvestigaciónNeutrófilosPlaquetasCiclofosfamidaEnfermedad de Hodgkin10.1038/bmt.2016.1151476-5365