Medina, Miguel Ángel2023-01-252023-01-252018-02-07http://hdl.handle.net/10668/12249Systemic approaches are needed and useful for the study of the very complex issue of cancer. Modeling has a central position in these systemic approaches. Metabolic reprogramming is nowadays acknowledged as an essential hallmark of cancer. Mathematical modeling could contribute to a better understanding of cancer metabolic reprogramming and to identify new potential ways of therapeutic intervention. Herein, I review several alternative approaches to metabolic modeling and their current and future impact in oncology.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/CancerMathematical modelMetabolismSystems biologyTumor microenvironmentAnimalsCellular ReprogrammingHumansMedical OncologyMetabolic Networks and PathwaysModels, TheoreticalNeoplasmsresearch article29548484open access10.1016/j.critrevonc.2018.02.0041879-0461https://riuma.uma.es/xmlui/bitstream/10630/16664/1/2018-04-CROH.pdf