Fogacci, FedericaRizzo, ManfrediKrogager, ChristofferKennedy, CormacGeorges, Coralie M.G.Knežević, TamaraLiberopoulos, EvangelosVallée, AlexandrePérez-Martínez, PabloWenstedt, Eliane F.E.Šatrauskienė, AgnėVrablík, MichalCicero, Arrigo F.G.2022-07-152022-07-152020-10-19Fogacci F, Rizzo M, Krogager C, Kennedy C, Georges CMG, Knežević T, et al. Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies. Antioxidants. 2020 Oct 19;9(10):1011http://hdl.handle.net/10668/3792Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta-analysis of the available randomized placebo-controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA and 2294 assigned to placebo. A meta-analysis of extracted data suggested that supplementation with ALA was not associated with an increased risk of any treatment-emergent adverse event (all p > 0.05). ALA supplementation was safe, even in subsets of studies categorized according to smoking habit, cardiovascular disease, presence of diabetes, pregnancy status, neurological disorders, rheumatic affections, severe renal impairment, and status of children/adolescents at baseline.33 p.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Alpha-lipoic acidThioctic acidDietary supplementSafetyMeta-analysisÁcido tiócticoSuplementos dietéticosSeguridadMetaanálisisRevisión sistemáticaMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiophenes::Thioctic AcidMedical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dietary SupplementsMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Accidents::Accident Prevention::SafetyMedical Subject Headings::Publication Type::Study Characteristics::Meta-AnalysisMedical Subject Headings::Diseases::Cardiovascular DiseasesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as TopicMedical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::PlacebosMedical Subject Headings::Diseases::Nervous System DiseasesMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Food Habits::SmokingMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::AntioxidantsMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Volatileresearch article33086555open access10.3390/antiox91010112076-3921PMC7603186