Rivera-Izquierdo, MarioSoler-Iborte, Evade Rojas, Javier PerezPegalajar-Garcia, Maria DoloresGil-Villalba, AnaRuiz-Villaverde, RicardoValero-Ubierna, Maria Del Carmen2023-05-032023-05-032021-12-21Rivera-Izquierdo M, Soler-Iborte E, de Rojas JP, Pegalajar-García MD, Gil-Villalba A, Ruiz-Villaverde R, et al . Factors Associated with Adverse Reactions to BNT162b2 COVID-19 Vaccine in a Cohort of 3969 Hospital Workers. Vaccines (Basel). 2021 Dec 23;10(1):15.2076-393Xhttp://hdl.handle.net/10668/21604Factors associated with adverse reactions to BNT162b2 COVID-19 vaccine reported by hospital workers are unclear. Our aim was to collect all reported adverse events in a cohort of hospital workers and to analyze the factors associated with their presence. We conducted an observational longitudinal study on all hospital workers of our center who received COVID-19 vaccination from 27 December 2020 to 1 September 2021. Information on adverse events was reported telephonically and confirmed through clinical records. Chi-square and t tests as well as multivariate logistic regression models were used. Cluster analysis was designed to explore associations between reactions. A total of 3969 hospital workers were included in the sample. Of the total sample, 182 workers (4.6%) reported adverse events. The most frequent symptoms were general malaise (n = 95), fever (n = 92), arthromyalgia (n = 80), and headache (n = 47). The factors associated with adverse events in adjusted analyses were an antecedent of COVID-19 infection (OR = 2.09, 95% CI: 1.47-2.98), female sex (OR = 1.51, 95% CI: 1.03-2.20), and professional category (OR for physicians = 0.41, 95% CI: 0.21-0.80). We report a low frequency of adverse events in hospital workers after COVID-19 vaccination and no severe reaction. Men and physicians underreported their symptoms. These data should guide future strategies for recording adverse events and future research on COVID-19 vaccination safety.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19ComirnatyPfizeradverse eventshealthcareprofessionalsreactionssymptomsvaccinationHumansMaleFemaleCOVID-19 VaccinesBNT162 VaccineLongitudinal StudiesLogistic ModelsCOVID-19PhysiciansVaccinationHeadacheCluster AnalysisHospitalsresearch article35062676open accessAnálisis por conglomeradosCefaleaEstudios longitudinalesFemeninoHospitalesHumanosMasculinoModelos logísticosMédicosVacuna BNT162VacunaciónVacunas contra la COVID-1910.3390/vaccines10010015PMC8777949https://www.mdpi.com/2076-393X/10/1/15/pdf?version=1640333860https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777949/pdf