Perez-Nadales, ElenaAlastruey-Izquierdo, AnaLinares-Sicilia, Maria JoseSoto-Debran, Juan CarlosAbdala, EdsonGarcía-Rodriguez, JulioMontejo, MiguelMuñoz, PatriciaLleti, Miguel SalavertRezusta, Antoniode Pipaon, Maite Ruiz PerezYañez, LucreciaMerino, EsperanzaCampos-Herrero, Maria IsolinaCosta-Mateo, Jose MariaFortun, JesusGarcia-Lozano, TomasGarcia-Vidal, CarolinaFernandez-Ruiz, MarioSanchez-Reus, FerranCastro-Mendez, CarmenGuerrero-Lozano, InmaculadaSoler-Palacin, PereAguado, Jose MariaMartinez-Martinez, LuisTorre-Cisneros, JulianNucci, Marcio2023-02-092023-02-092021Pérez-Nadales E, Alastruey-Izquierdo A, Linares-Sicilia MJ, Soto-Debrán JC, Abdala E, García-Rodríguez J, et al. Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015. Emerg Infect Dis. 2021 Jan;27(1):26–3http://hdl.handle.net/10668/16833Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000-2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000-2009 to 0.22 cases per 100,000 admissions in 2010-2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/FusariumSpainFungal infectionsFungiFusariosisIncidenceInvasive fusariosisMortalityMycotic diseasesNeutropeniaÁrea de Gestión Sanitaria Sur de SevillaAntifungal agentsFusariosisFusariumHumansNeutropeniaObservational studies as topicSpainresearch article33352085open accessAntifúngicosEspañaEstudios observacionales como asuntoNeutropenia10.3201/eid2701.1907821080-6059PMC7774531https://wwwnc.cdc.gov/eid/article/27/1/pdfs/19-0782.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774531/pdf