García-Fuentes, EduardoGallo, ManuelGarcía, LaureanoPrieto, StephanieAlcaide-Torres, JavierSantiago, PiedadVelasco, InésSoriguer, Federico2013-10-022013-10-022008-06García-Fuentes E, Gallo M, García L, Prieto S, Alcaide-Torres J, Santiago P, et al. Amniotic fluid iodine concentrations do not vary in pregnant women with varying iodine intake. Br. J. Nutr.. 2008; 99(6):1178-810007-1145http://hdl.handle.net/10668/1305Comparative Study; Journal Article; Research Support, Non-U.S. Gov't;Iodine deficiency is an important clinical and public health problem. Its prevention begins with an adequate intake of iodine during pregnancy. International agencies recommend at least 200 microg iodine per d for pregnant women. We assessed whether iodine concentrations in the amniotic fluid of healthy pregnant women are independent of iodine intake. This cross-sectional, non-interventional study included 365 consecutive women who underwent amniocentesis to determine the fetal karyotype. The amniocentesis was performed with abdominal antisepsis using chlorhexidine. The iodine concentration was measured in urine and amniotic fluid. The study variables were the intake of iodized salt and multivitamin supplements or the prescription of a KI supplement. The mean level of urinary iodine was 139.0 (SD 94.5) microg/l and of amniotic fluid 15.81 (SD 7.09) microg/l. The women who consumed iodized salt and those who took a KI supplement had significantly higher levels of urinary iodine than those who did not (P = 0.01 and P = 0.004, respectively). The urinary iodine levels were not significantly different in the women who took a multivitamin supplement compared with those who did not take this supplement, independently of iodine concentration or multivitamin supplement. The concentrations of iodine in the amniotic fluid were similar, independent of the dietary iodine intake. Urine and amniotic fluid iodine concentrations were weakly correlated, although the amniotic fluid values were no higher in those women taking a KI supplement. KI prescription at recommended doses increases the iodine levels in the mother without influencing the iodine levels in the amniotic fluid.enIodineAmniotic fluidPregnancyLíquido amnióticoYodoEmbarazoSuplementos DietéticosEstado NutricionalYoduro potásicoCloruro sódico dietéticoMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Obstetrical and Gynecological::Prenatal Diagnosis::AmniocentesisMedical Subject Headings::Anatomy::Fluids and Secretions::Amniotic FluidMedical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Dietary SupplementsMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Halogens::IodineMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle AgedMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional StatusMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Iodine Compounds::Iodides::Potassium IodideMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::PregnancyMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Pregnancy Trimesters::Pregnancy Trimester, SecondMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Sodium Compounds::Sodium Chloride::Sodium Chloride, DietaryMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Statistics, NonparametricMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Micronutrients::VitaminsMedical Subject Headings::Named Groups::Persons::Age Groups::Adultresearch article18205989open access10.1017/S00071145078623981475-2662