O'Gorman, NWright, DPoon, L CRolnik, D LSyngelaki, AWright, AAkolekar, RCicero, SJanga, DJani, JMolina, F Sde Paco Matallana, CPapantoniou, NPersico, NPlasencia, WSingh, MNicolaides, K H2023-01-252023-01-252017-05-14http://hdl.handle.net/10668/10757To examine the diagnostic accuracy of a previously developed model for prediction of pre-eclampsia (PE) by a combination of maternal factors and biomarkers at 11-13 weeks' gestation. This was a prospective first-trimester multicenter study of screening for PE in 8775 singleton pregnancies. A previously published algorithm was used for the calculation of patient-specific risk of PE in each individual. The detection rates (DRs) and false-positive rates (FPRs) for delivery with PE In the study population, 239 (2.7%) cases developed PE, of which 17 (0.2%), 59 (0.7%) and 180 (2.1%) developed PE Assessment of a combination of maternal factors and biomarkers at 11-13 weeks provides effective first-trimester screening for preterm PE. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.enBayes' theoremfirst-trimester screeningmean arterial pressureplacental growth factorpre-eclampsiapregnancy-associated plasma protein-Apyramid of pregnancy caresurvival modeluterine artery DopplerAdultBiomarkersEuropeFemaleGestational AgeHumansModels, TheoreticalPlacenta Growth FactorPre-EclampsiaPregnancyPregnancy Trimester, FirstPrenatal DiagnosisProspective StudiesPulsatile FlowRisk AssessmentSensitivity and SpecificityUterine Arteryresearch article28067011open access10.1002/uog.173991469-0705https://obgyn.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/uog.17399