Sanchez-Rodriguez, EstefaniaEgea-Zorrilla, AlejandroPlaza-Díaz, JulioAragón-Vela, JerónimoMuñoz-Quezada, SergioTercedor-Sánchez, LuisAbadia-Molina, Francisco2022-05-032022-05-032020-02-26Sanchez-Rodriguez E, Egea-Zorrilla A, Plaza-Díaz J, Aragón-Vela J, Muñoz-Quezada S, Tercedor-Sánchez L, et al. The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases. Nutrients. 2020 Feb 26;12(3):605http://hdl.handle.net/10668/3611The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be considered in the pathogenesis of cardiovascular diseases (CVDs). In this review, we briefly discuss how external factors such as dietary and physical activity habits influence host-microbiota and atherogenesis, the potential mechanisms of the influence of gut microbiota in host blood pressure and the alterations in the prevalence of those bacterial genera affecting vascular tone and the development of hypertension. We will also be examining the microbiota as a therapeutic target in the prevention of CVDs and the beneficial mechanisms of probiotic administration related to cardiovascular risks. All these new insights might lead to novel analysis and CVD therapeutics based on the microbiota.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Cardiovascular diseasesAtherosclerosisGut microbiotaMicrobiomeEnfermedades cardiovascularesAterosclerosisMicrobioma gastrointestinalMicrobiotaMedical Subject Headings::Organisms::Eukaryota::AnimalsMedical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::AtherosclerosisMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Molecular Targeted TherapyMedical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements::ProbioticsMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::MicrobiotaMedical Subject Headings::Diseases::Cardiovascular DiseasesMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::DysbiosisMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habitsreview article32110880open access10.3390/nu120306052072-6643PMC7146472