Fortner, Renée THüsing, AnikaKühn, TilmanKonar, MericOvervad, KimTjønneland, AnneHansen, LouiseBoutron-Ruault, Marie-ChristineSeveri, GianlucaFournier, AgnèsBoeing, HeinerTrichopoulou, AntoniaBenetou, VasilikiOrfanos, PhilipposMasala, GiovannaAgnoli, ClaudiaMattiello, AmaliaTumino, RosarioSacerdote, CarlottaBueno-de-Mesquita, H B AsPeeters, Petra H MWeiderpass, ElisabeteGram, Inger TGavrilyuk, OxanaQuirós, J RamónMaria Huerta, JoséArdanaz, EvaLarrañaga, NereaLujan-Barroso, LeilaSánchez-Cantalejo, EmilioButt, Salma TunåBorgquist, SigneIdahl, AnnikaLundin, EvaKhaw, Kay-TeeAllen, Naomi ERinaldi, SabinaDossus, LaureGunter, MarcMerritt, Melissa ATzoulaki, IoannaRiboli, ElioKaaks, Rudolf2023-01-252023-01-252017http://hdl.handle.net/10668/10666Endometrial cancer risk prediction models including lifestyle, anthropometric and reproductive factors have limited discrimination. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. Serum concentrations of sex steroid hormones, metabolic markers, growth factors, adipokines and cytokines were evaluated in a step-wise backward selection process; biomarkers were retained at p enadipokinescytokinesendometrial cancergrowth factorsinflammatory markerslipidsmetabolic markersprospective cohortrisk predictionsex steroidsAdultAgedBiomarkers, TumorBlood GlucoseBlood ProteinsCase-Control StudiesComorbidityCytokinesEndometrial NeoplasmsEuropeFemaleFollow-Up StudiesHormonesHumansIncidenceInflammationLipidsMetabolic SyndromeMiddle AgedRiskRisk AssessmentSingle-Blind MethodSurveys and Questionnairesresearch article27935083open access10.1002/ijc.305601097-0215https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.30560