Yélamos, OriolNavarrete-Dechent, CristiánMarchetti, Michael ARogers, TovaApalla, ZoeBahadoran, PhilippeBlázquez-Sánchez, NuriaBusam, KlausCarrera, CristinaDusza, Stephen Wde la Fouchardière, ArnaudFerrara, GerardoGerami, PedramKittler, HaraldLallas, AimiliosMalvehy, JosepMillán-Cayetano, José FNelson, Kelly CQuan, Victor LiPuig, SusanaStevens, HowardThomas, LucMarghoob, Ashfaq A2025-01-072025-01-072018-09-20https://hdl.handle.net/10668/26652Multiple BRCA1-associated protein 1 (BAP1)-inactivated melanocytic tumors (BIMTs) have been associated with a familial cancer syndrome involving germline mutations in BAP1. We sought to describe the clinical and dermoscopic features of BIMTs. This was a retrospective, multicenter, case-control study. Participating centers contributed clinical data, dermoscopic images, and histopathologic data of biopsy-proven BIMTs. We compared the dermoscopic features between BIMTs and control patients. The dataset consisted of 48 BIMTs from 31 patients (22 women; median age 37 years) and 80 control patients. Eleven patients had a BAP1 germline mutation. Clinically, most BIMTs presented as pink, dome-shaped papules (n = 24). Dermoscopically, we identified 5 patterns: structureless pink-to-tan with irregular eccentric dots/globules (n = 14, 29.8%); structureless pink-to-tan with peripheral vessels (n = 10, 21.3%); structureless pink-to-tan (n = 7, 14.9%); a network with raised, structureless, pink-to-tan areas (n = 7, 14.9%); and globular pattern (n = 4, 8.5%). The structureless with eccentric dots/globules pattern and network with raised structureless areas pattern were only identified in BIMT and were more common in patients with BAP1 germline mutations (P  Limitations included our small sample size, retrospective design, the absence of germline genetic testing in all patients, and inclusion bias toward more atypical-looking BIMTs. Dome-shaped papules with pink-to-tan structureless areas and peripheral irregular dots/globules or network should raise the clinical suspicion for BIMT.enBAP1BAP1-inactivated melanocytic tumorsWiesner nevusatypical Spitzoid tumordermoscopymelanomaAdolescentAdultAgedBiopsyCase-Control StudiesChildDatabases, FactualDermoscopyFemaleGerm-Line MutationHumansMaleMelanomaMiddle AgedNeoplasms, Multiple PrimaryNeoplastic Syndromes, HereditaryNevus, Epithelioid and Spindle CellNevus, PigmentedObserver VariationRetrospective StudiesSample SizeSingle-Blind MethodSkin NeoplasmsTumor Suppressor ProteinsUbiquitin ThiolesteraseYoung Adultresearch article30244062open access10.1016/j.jaad.2018.09.0141097-6787PMC6426687https://europepmc.org/articles/pmc6426687?pdf=renderhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6426687/pdf