Sanchez-Larsen, AlvaroConde-Blanco, EstefaníaViloria-Alebesque, AlejandroSánchez-Vizcaíno Buendía, CristinaEspinosa Oltra, TatianaAlvarez-Noval, AmandaAledo-Serrano, AngelMartin-Garcia, RaquelRamos-Araque, María ECampos, DulceValle-Peñacoba, GonzaloSierra-Gómez, AliciaDe Ceballos-Cerrajería, PabloAgundez-Sarasola, MartaKhawaja, MariamHampel, Kevin GSerra-Martínez, MariaArbós-Barber, ClaraGómez-Ibáñez, AsierVillino-Boquete, RafaelCabezudo-García, PabloRodríguez-Lavado, IgnacioPrincipe, AlessandroSopelana-Garay, David2025-01-072025-01-072021-10-08https://hdl.handle.net/10668/24531To assess the prevalence, severity, and mortality of COVID-19 in people with epilepsy (PWE) and evaluate seizure control in PWE during and after COVID-19. Retrospective, observational, multicenter study conducted in 14 hospitals. Medical records of randomly selected PWE followed at neurology outpatient clinics were reviewed. Proportion of PWE with a positive test for SARS-CoV-2 during 2020 was calculated. Risk factors associated with COVID-19 and its morbimortality were evaluated. 2751 PWE were included, mean age 48.8 years (18-99), 72.4% had focal epilepsy, and 35% were drug-refractory. COVID-19 prevalence in PWE was 5.53%, while in the Spanish population was 4.26%. Proportion of admissions to hospital, ICU, and deaths in PWE were 17.1%, 2%, and 4.61% of COVID-19 cases, while in Spanish population were 10.81%, 0.95%, and 2.57%, respectively. A severe form of COVID-19 occurred in 11.8%; dyslipidemia, institutionalization at long-term care facilities, intellectual disability, and older age were associated risk factors. Older age, hypertension, dyslipidemia, cardiac disease, and institutionalization were associated with mortality from COVID-19. Seizure control was stable in 90.1% of PWE during acute COVID-19, while 8.6% reported an increase in seizure frequency. During post-COVID-19 follow-up, 4.6% reported seizure control worsening. COVID-19 was moderately prevalent in PWE. One out of 5 patients required medical attention and 4.6% died due to COVID-19. Older age, dyslipidemia, institutionalization, and intellectual disability were significant risk factors associated with severe COVID-19. Seizure control remained stable during COVID-19 and throughout long-term follow-up in most PWE who contracted the infection.enCOVID-19Coronavirus, SARS-CoV-2EpilepsyPrevalenceSeizuresAgedCOVID-19EpilepsyHumansMiddle AgedPrevalenceRetrospective StudiesSARS-CoV-2research article34731719open access10.1016/j.yebeh.2021.1083791525-5069PMC9759834https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759834https://pmc.ncbi.nlm.nih.gov/articles/PMC9759834/pdf