Domínguez-Sánchez, María S.Sáez, CarmenJapón, Miguel A.Aguilera, AndrésLuna, Rosa2012-01-272012-01-272011-02-17Domínguez-Sánchez MS, Sáez C, Japón MA, Aguilera A, Luna R. Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer. 2011 Feb 17;11:77.http://hdl.handle.net/10668/287One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples.enNeoplasias de la MamaProteínas NuclearesRibonucleoproteínasProteínas de Unión al ARNProteínas de Ciclo CelularMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast NeoplasmsMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Nuclear ProteinsMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Carrier Proteins::RNA-Binding Proteins::RibonucleoproteinsMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Cell Cycle Proteinsresearch articleopen access10.1186/1471-2407-11-771471-2407