Ruiz-Sánchez, Jorge GabrielCuesta, MartínGómez-Hoyos, EmiliaCárdenas-Salas, JersyRubio-Herrera, Miguel ÁngelMartínez-González, EstefaníaDe Miguel Novoa, PazTernero-Vega, Jara EloisaCalle-Pascual, Alfonso LuisRunkle, Isabelle2023-05-032023-05-032022-06-25http://hdl.handle.net/10668/21426Background and Objectives: Differentiating between hypovolemic (HH) and euvolemic hyponatremia (EH) is crucial for correct diagnosis and therapy, but can be a challenge. We aim to ascertain whether changes in serum creatinine (SC) can be helpful in distinguishing HH from EH. Materials and Methods: Retrospective analysis of patients followed in a monographic hyponatremia outpatient clinic of a tertiary hospital during 1 January 2014−30 November 2019. SC changes during HH and EH from eunatremia were studied. The diagnostic accuracy of the SC change from eunatremia to hyponatremia (∆SC) was analyzed. Results: A total of 122 hyponatremic patients, median age 79 years (70−85), 46.7% women. In total, 70/122 patients had EH, 52/122 HH. During hyponatremia, median SC levels increased in the HH group: +0.18 mg/dL [0.09−0.39, penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/SIADeuvolemic hyponatremiahyponatremiahypovolemic hyponatremiaserum creatinineAgedCreatinineFemaleHumansHyponatremiaHypovolemiaMaleROC CurveRetrospective Studiesresearch article35888570open access10.3390/medicina580708511648-9144PMC9323891https://www.mdpi.com/1648-9144/58/7/851/pdf?version=1656323245https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323891/pdf