Artacho-Cordón, FranciscoSalinas-Asensio, María del MarCalvente, IreneRíos-Arrabal, SandraLeón, JosefaRomán-Marinetto, ElisaOlea, NicolásNúñez, María Isabel2015-09-112015-09-112013-07Artacho-Cordón F, Salinas-Asensio Mdel M, Calvente I, Ríos-Arrabal S, León J, Román-Marinetto E, et al. Could radiotherapy effectiveness be enhanced by electromagnetic field treatment? Int J Mol Sci. 2013; 14(7):14974-95http://hdl.handle.net/10668/1992Journal Article; Research Support, Non-U.S. Gov't; Review;One of the main goals in radiobiology research is to enhance radiotherapy effectiveness without provoking any increase in toxicity. In this context, it has been proposed that electromagnetic fields (EMFs), known to be modulators of proliferation rate, enhancers of apoptosis and inductors of genotoxicity, might control tumor recruitment and, thus, provide therapeutic benefits. Scientific evidence shows that the effects of ionizing radiation on cellular compartments and functions are strengthened by EMF. Although little is known about the potential role of EMFs in radiotherapy (RT), the radiosensitizing effect of EMFs described in the literature could support their use to improve radiation effectiveness. Thus, we hypothesized that EMF exposure might enhance the ionizing radiation effect on tumor cells, improving the effects of RT. The aim of this paper is to review reports of the effects of EMFs in biological systems and their potential therapeutic benefits in radiotherapy.enELF Magnetic ExposureElectromagnetic FieldsCancerRadiotherapyGenotocityCampos electromagnéticosNeoplasiasRadiación ionizanteSistema de señalización de quinasas PAMMedical Subject Headings::Anatomy::Cells::Cellular Structures::Cell MembraneMedical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cell NucleusMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Magnetic Phenomena::Electromagnetic Phenomena::Electromagnetic FieldsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction::MAP Kinase Signaling SystemMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Radiation::Radiation, IonizingMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Radiation-Sensitizing AgentsMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosisreview article23867611open access10.3390/ijms1407149741422-0067PMC3742283