Mateo, JoaquinBoysen, GuntherBarbieri, Christopher EBryant, Helen ECastro, ElenaNelson, Pete SOlmos, DavidPritchard, Colin CRubin, Mark Ade-Bono, Johann S2023-01-252023-01-252017-01-19Mateo J, Boysen G, Barbieri CE, Bryant HE, Castro E, Nelson PS, et al. DNA Repair in Prostate Cancer: Biology and Clinical Implications. Eur Urol. 2017 Mar;71(3):417-425http://hdl.handle.net/10668/10413For more precise, personalized care in prostate cancer (PC), a new classification based on molecular features relevant for prognostication and treatment stratification is needed. Genomic aberrations in the DNA damage repair pathway are common in PC, particularly in late-stage disease, and may be relevant for treatment stratification. To review current knowledge on the prevalence and clinical significance of aberrations in DNA repair genes in PC, particularly in metastatic disease. A literature search up to July 2016 was conducted, including clinical trials and preclinical basic research studies. Keywords included DNA repair, BRCA, ATM, CRPC, prostate cancer, PARP, platinum, predictive biomarkers, and hereditary cancer. We review how the DNA repair pathway is relevant to prostate carcinogenesis and progression. Data on how this may be relevant to hereditary cancer and genetic counseling are included, as well as data from clinical trials of PARP inhibitors and platinum therapeutics in PC. Relevant studies have identified genomic defects in DNA repair in PCs in 20-30% of advanced castration-resistant PC cases, a proportion of which are germline aberrations and heritable. Phase 1/2 clinical trial data, and other supporting clinical data, support the development of PARP inhibitors and DNA-damaging agents in this molecularly defined subgroup of PC following success in other cancer types. These studies may be an opportunity to improve patient care with personalized therapeutic strategies. Key literature on how genomic defects in the DNA damage repair pathway are relevant for prostate cancer biology and clinical management is reviewed. Potential implications for future changes in patient care are discussed.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/BRCADNA damageDNA repairPARPPersonalized medicineProstate cancerAtaxia Telangiectasia Mutated ProteinsBRCA1 ProteinBRCA2 ProteinDNA Mismatch RepairDNA RepairHumansMaleMolecular Diagnostic TechniquesMutL Protein Homolog 1MutS Homolog 2 ProteinPoly(ADP-ribose) Polymerase InhibitorsPrecision MedicinePrognosisProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantRecombinational DNA Repairresearch article27590317open accessReparación del ADNNeoplasias de la PróstataInhibidores de Poli(ADP-Ribosa) PolimerasasDaño del ADNAsesoramiento Genético10.1016/j.eururo.2016.08.0371873-7560http://www.europeanurology.com/article/S0302283816305048/pdf